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Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population

Spatial normalization is an important step for group image processing and evaluation of mean brain perfusion in anatomical regions using arterial spin labeling (ASL) MRI and is typically performed via high-resolution structural brain scans. However, structural segmentation and/or spatial normalizati...

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Autores principales: de Planque, Catherine A., Mutsaerts, Henk J. M. M., Keil, Vera C., Erler, Nicole S., Dremmen, Marjolein H. G., Mathijssen, Irene M. J., Petr, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326566/
https://www.ncbi.nlm.nih.gov/pubmed/34349619
http://dx.doi.org/10.3389/fnins.2021.698007
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author de Planque, Catherine A.
Mutsaerts, Henk J. M. M.
Keil, Vera C.
Erler, Nicole S.
Dremmen, Marjolein H. G.
Mathijssen, Irene M. J.
Petr, Jan
author_facet de Planque, Catherine A.
Mutsaerts, Henk J. M. M.
Keil, Vera C.
Erler, Nicole S.
Dremmen, Marjolein H. G.
Mathijssen, Irene M. J.
Petr, Jan
author_sort de Planque, Catherine A.
collection PubMed
description Spatial normalization is an important step for group image processing and evaluation of mean brain perfusion in anatomical regions using arterial spin labeling (ASL) MRI and is typically performed via high-resolution structural brain scans. However, structural segmentation and/or spatial normalization to standard space is complicated when gray-white matter contrast in structural images is low due to ongoing myelination in newborns and infants. This problem is of particularly clinical relevance for imaging infants with inborn or acquired disorders that impair normal brain development. We investigated whether the ASL MRI perfusion contrast is a viable alternative for spatial normalization, using a pseudo-continuous ASL acquired using a 1.5 T MRI unit (GE Healthcare). Four approaches have been compared: (1) using the structural image contrast, or perfusion contrast with (2) rigid, (3) affine, and (4) nonlinear transformations – in 16 healthy controls [median age 0.83 years, inter-quartile range (IQR) ± 0.56] and 36 trigonocephaly patients (median age 0.50 years, IQR ± 0.30) – a non-syndromic type of craniosynostosis. Performance was compared quantitatively using the real-valued Tanimoto coefficient (TC), visually by three blinded readers, and eventually by the impact on regional cerebral blood flow (CBF) values. For both patients and controls, nonlinear registration using perfusion contrast showed the highest TC, at 17.51 (CI 6.66–49.38) times more likely to have a higher rating and 17.45–18.88 ml/100 g/min higher CBF compared with the standard normalization. Using perfusion-based contrast improved spatial normalization compared with the use of structural images, significantly affected the regional CBF, and may open up new possibilities for future large pediatric ASL brain studies.
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spelling pubmed-83265662021-08-03 Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population de Planque, Catherine A. Mutsaerts, Henk J. M. M. Keil, Vera C. Erler, Nicole S. Dremmen, Marjolein H. G. Mathijssen, Irene M. J. Petr, Jan Front Neurosci Neuroscience Spatial normalization is an important step for group image processing and evaluation of mean brain perfusion in anatomical regions using arterial spin labeling (ASL) MRI and is typically performed via high-resolution structural brain scans. However, structural segmentation and/or spatial normalization to standard space is complicated when gray-white matter contrast in structural images is low due to ongoing myelination in newborns and infants. This problem is of particularly clinical relevance for imaging infants with inborn or acquired disorders that impair normal brain development. We investigated whether the ASL MRI perfusion contrast is a viable alternative for spatial normalization, using a pseudo-continuous ASL acquired using a 1.5 T MRI unit (GE Healthcare). Four approaches have been compared: (1) using the structural image contrast, or perfusion contrast with (2) rigid, (3) affine, and (4) nonlinear transformations – in 16 healthy controls [median age 0.83 years, inter-quartile range (IQR) ± 0.56] and 36 trigonocephaly patients (median age 0.50 years, IQR ± 0.30) – a non-syndromic type of craniosynostosis. Performance was compared quantitatively using the real-valued Tanimoto coefficient (TC), visually by three blinded readers, and eventually by the impact on regional cerebral blood flow (CBF) values. For both patients and controls, nonlinear registration using perfusion contrast showed the highest TC, at 17.51 (CI 6.66–49.38) times more likely to have a higher rating and 17.45–18.88 ml/100 g/min higher CBF compared with the standard normalization. Using perfusion-based contrast improved spatial normalization compared with the use of structural images, significantly affected the regional CBF, and may open up new possibilities for future large pediatric ASL brain studies. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8326566/ /pubmed/34349619 http://dx.doi.org/10.3389/fnins.2021.698007 Text en Copyright © 2021 de Planque, Mutsaerts, Keil, Erler, Dremmen, Mathijssen and Petr. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
de Planque, Catherine A.
Mutsaerts, Henk J. M. M.
Keil, Vera C.
Erler, Nicole S.
Dremmen, Marjolein H. G.
Mathijssen, Irene M. J.
Petr, Jan
Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population
title Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population
title_full Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population
title_fullStr Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population
title_full_unstemmed Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population
title_short Using Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population
title_sort using perfusion contrast for spatial normalization of asl mri images in a pediatric craniosynostosis population
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326566/
https://www.ncbi.nlm.nih.gov/pubmed/34349619
http://dx.doi.org/10.3389/fnins.2021.698007
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