Cargando…

Colon carcinoma presenting as ovarian metastasis

An adnexal mass is a common gynecological finding. Most adnexal masses are benign neoplasms, especially in premenopausal women. Yet, here we report a premenopausal woman with an adnexal mass that turned out to be an ovarian metastasis from colon cancer. This case emphasizes the importance of conside...

Descripción completa

Detalles Bibliográficos
Autores principales: Kemps, Paul Geraeds, Bol, Mijke, Steller, Ernst Johan Abraham, de Pont, Lisa Maria Henrica, Holterhues, Cynthia, van Gerven, Leander, Kolkman, Wendela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326593/
https://www.ncbi.nlm.nih.gov/pubmed/34367398
http://dx.doi.org/10.1016/j.radcr.2021.06.072
_version_ 1783731859962724352
author Kemps, Paul Geraeds
Bol, Mijke
Steller, Ernst Johan Abraham
de Pont, Lisa Maria Henrica
Holterhues, Cynthia
van Gerven, Leander
Kolkman, Wendela
author_facet Kemps, Paul Geraeds
Bol, Mijke
Steller, Ernst Johan Abraham
de Pont, Lisa Maria Henrica
Holterhues, Cynthia
van Gerven, Leander
Kolkman, Wendela
author_sort Kemps, Paul Geraeds
collection PubMed
description An adnexal mass is a common gynecological finding. Most adnexal masses are benign neoplasms, especially in premenopausal women. Yet, here we report a premenopausal woman with an adnexal mass that turned out to be an ovarian metastasis from colon cancer. This case emphasizes the importance of considering an ovarian metastasis in patients with (partially) solid adnexal masses and low serum CA125 levels. In addition, we identified the same KRAS mutation in the biopsied liver metastasis and resected right ovarian metastasis. This is in accordance with a previous molecular study of matched tumor pairs/trios of colorectal cancer patients with ovarian metastases, suggesting that mutated KRAS is a universal driver of the metastatic disease in women with KRAS-mutated colorectal cancer with ovarian metastases. More than half of all colorectal cancer patients with ovarian metastases harbor KRAS mutations. Future studies may investigate the efficacy of KRAS inhibitors in the treatment of these patients.
format Online
Article
Text
id pubmed-8326593
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-83265932021-08-06 Colon carcinoma presenting as ovarian metastasis Kemps, Paul Geraeds Bol, Mijke Steller, Ernst Johan Abraham de Pont, Lisa Maria Henrica Holterhues, Cynthia van Gerven, Leander Kolkman, Wendela Radiol Case Rep Case Report An adnexal mass is a common gynecological finding. Most adnexal masses are benign neoplasms, especially in premenopausal women. Yet, here we report a premenopausal woman with an adnexal mass that turned out to be an ovarian metastasis from colon cancer. This case emphasizes the importance of considering an ovarian metastasis in patients with (partially) solid adnexal masses and low serum CA125 levels. In addition, we identified the same KRAS mutation in the biopsied liver metastasis and resected right ovarian metastasis. This is in accordance with a previous molecular study of matched tumor pairs/trios of colorectal cancer patients with ovarian metastases, suggesting that mutated KRAS is a universal driver of the metastatic disease in women with KRAS-mutated colorectal cancer with ovarian metastases. More than half of all colorectal cancer patients with ovarian metastases harbor KRAS mutations. Future studies may investigate the efficacy of KRAS inhibitors in the treatment of these patients. Elsevier 2021-07-23 /pmc/articles/PMC8326593/ /pubmed/34367398 http://dx.doi.org/10.1016/j.radcr.2021.06.072 Text en © 2021 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kemps, Paul Geraeds
Bol, Mijke
Steller, Ernst Johan Abraham
de Pont, Lisa Maria Henrica
Holterhues, Cynthia
van Gerven, Leander
Kolkman, Wendela
Colon carcinoma presenting as ovarian metastasis
title Colon carcinoma presenting as ovarian metastasis
title_full Colon carcinoma presenting as ovarian metastasis
title_fullStr Colon carcinoma presenting as ovarian metastasis
title_full_unstemmed Colon carcinoma presenting as ovarian metastasis
title_short Colon carcinoma presenting as ovarian metastasis
title_sort colon carcinoma presenting as ovarian metastasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326593/
https://www.ncbi.nlm.nih.gov/pubmed/34367398
http://dx.doi.org/10.1016/j.radcr.2021.06.072
work_keys_str_mv AT kempspaulgeraeds coloncarcinomapresentingasovarianmetastasis
AT bolmijke coloncarcinomapresentingasovarianmetastasis
AT stellerernstjohanabraham coloncarcinomapresentingasovarianmetastasis
AT depontlisamariahenrica coloncarcinomapresentingasovarianmetastasis
AT holterhuescynthia coloncarcinomapresentingasovarianmetastasis
AT vangervenleander coloncarcinomapresentingasovarianmetastasis
AT kolkmanwendela coloncarcinomapresentingasovarianmetastasis