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The emerging role of circular RNAs in spinal cord injury()

Spinal cord injury (SCI) is one kind of severe diseases with high mortality and morbidity worldwide, and lacks effective therapeutic interventions currently, which leads to not only permanent neurological impairments but also heavy social and economic burden. Recent studies have proved that circRNAs...

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Autores principales: Peng Peng, Yu, Hao, Yongjin Li, Huang, Jingyuan, Yao, Shengyu, Xing, Cong, Liu, Weixiao, Zhang, Bin, Feng, Shiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326601/
https://www.ncbi.nlm.nih.gov/pubmed/34401327
http://dx.doi.org/10.1016/j.jot.2021.06.001
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author Peng Peng
Yu, Hao
Yongjin Li
Huang, Jingyuan
Yao, Shengyu
Xing, Cong
Liu, Weixiao
Zhang, Bin
Feng, Shiqing
author_facet Peng Peng
Yu, Hao
Yongjin Li
Huang, Jingyuan
Yao, Shengyu
Xing, Cong
Liu, Weixiao
Zhang, Bin
Feng, Shiqing
author_sort Peng Peng
collection PubMed
description Spinal cord injury (SCI) is one kind of severe diseases with high mortality and morbidity worldwide, and lacks effective therapeutic interventions currently, which leads to not only permanent neurological impairments but also heavy social and economic burden. Recent studies have proved that circRNAs are highly expressed in neural tissues, regulating the neuronal and synaptic functions. What's more, significantly altered circRNAs expression profiles are closely associated with the pathophysiology of SCI. In this review, we summarize the current advance on the role of circRNAs in SCI, which may provide a better understanding of pathogenesis and therapeutic strategies of SCI. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: The Translational potential of this article is that A further understanding of circRNAs in the pathogenesis of SCI will promote the circRNA-based clinical applications.
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spelling pubmed-83266012021-08-15 The emerging role of circular RNAs in spinal cord injury() Peng Peng Yu, Hao Yongjin Li Huang, Jingyuan Yao, Shengyu Xing, Cong Liu, Weixiao Zhang, Bin Feng, Shiqing J Orthop Translat Review Article Spinal cord injury (SCI) is one kind of severe diseases with high mortality and morbidity worldwide, and lacks effective therapeutic interventions currently, which leads to not only permanent neurological impairments but also heavy social and economic burden. Recent studies have proved that circRNAs are highly expressed in neural tissues, regulating the neuronal and synaptic functions. What's more, significantly altered circRNAs expression profiles are closely associated with the pathophysiology of SCI. In this review, we summarize the current advance on the role of circRNAs in SCI, which may provide a better understanding of pathogenesis and therapeutic strategies of SCI. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: The Translational potential of this article is that A further understanding of circRNAs in the pathogenesis of SCI will promote the circRNA-based clinical applications. Chinese Speaking Orthopaedic Society 2021-07-22 /pmc/articles/PMC8326601/ /pubmed/34401327 http://dx.doi.org/10.1016/j.jot.2021.06.001 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Peng Peng
Yu, Hao
Yongjin Li
Huang, Jingyuan
Yao, Shengyu
Xing, Cong
Liu, Weixiao
Zhang, Bin
Feng, Shiqing
The emerging role of circular RNAs in spinal cord injury()
title The emerging role of circular RNAs in spinal cord injury()
title_full The emerging role of circular RNAs in spinal cord injury()
title_fullStr The emerging role of circular RNAs in spinal cord injury()
title_full_unstemmed The emerging role of circular RNAs in spinal cord injury()
title_short The emerging role of circular RNAs in spinal cord injury()
title_sort emerging role of circular rnas in spinal cord injury()
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326601/
https://www.ncbi.nlm.nih.gov/pubmed/34401327
http://dx.doi.org/10.1016/j.jot.2021.06.001
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