Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel

SARS-CoV-2 Delta (B.1.617.2) variant of concern (VOC) and other VOCs are spreading in Europe. Micro-neutralisation assays with sera obtained after Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in 36 healthcare workers (31 female) demonstrated significant fold change reduction in neutralising tit...

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Autores principales: Lustig, Yaniv, Zuckerman, Neta, Nemet, Ital, Atari, Nofar, Kliker, Limor, Regev-Yochay, Gili, Sapir, Einav, Mor, Orna, Alroy-Preis, Sharon, Mendelson, Ella, Mandelboim, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326656/
https://www.ncbi.nlm.nih.gov/pubmed/34212838
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.26.2100557
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author Lustig, Yaniv
Zuckerman, Neta
Nemet, Ital
Atari, Nofar
Kliker, Limor
Regev-Yochay, Gili
Sapir, Einav
Mor, Orna
Alroy-Preis, Sharon
Mendelson, Ella
Mandelboim, Michal
author_facet Lustig, Yaniv
Zuckerman, Neta
Nemet, Ital
Atari, Nofar
Kliker, Limor
Regev-Yochay, Gili
Sapir, Einav
Mor, Orna
Alroy-Preis, Sharon
Mendelson, Ella
Mandelboim, Michal
author_sort Lustig, Yaniv
collection PubMed
description SARS-CoV-2 Delta (B.1.617.2) variant of concern (VOC) and other VOCs are spreading in Europe. Micro-neutralisation assays with sera obtained after Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in 36 healthcare workers (31 female) demonstrated significant fold change reduction in neutralising titres compared with the original virus: Gamma (P.1) 2.3, Beta (B.1.351) 10.4, Delta 2.1 and 2.6. The reduction of the Alpha (B.1.1.7) variant was not significant. Despite being lower, remaining neutralisation capacity conferred by Comirnaty against Delta and other VOCs is probably protective.
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spelling pubmed-83266562021-08-11 Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel Lustig, Yaniv Zuckerman, Neta Nemet, Ital Atari, Nofar Kliker, Limor Regev-Yochay, Gili Sapir, Einav Mor, Orna Alroy-Preis, Sharon Mendelson, Ella Mandelboim, Michal Euro Surveill Rapid Communication SARS-CoV-2 Delta (B.1.617.2) variant of concern (VOC) and other VOCs are spreading in Europe. Micro-neutralisation assays with sera obtained after Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in 36 healthcare workers (31 female) demonstrated significant fold change reduction in neutralising titres compared with the original virus: Gamma (P.1) 2.3, Beta (B.1.351) 10.4, Delta 2.1 and 2.6. The reduction of the Alpha (B.1.1.7) variant was not significant. Despite being lower, remaining neutralisation capacity conferred by Comirnaty against Delta and other VOCs is probably protective. European Centre for Disease Prevention and Control (ECDC) 2021-07-01 /pmc/articles/PMC8326656/ /pubmed/34212838 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.26.2100557 Text en This article is copyright of the authors or their affiliated institutions, 2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Lustig, Yaniv
Zuckerman, Neta
Nemet, Ital
Atari, Nofar
Kliker, Limor
Regev-Yochay, Gili
Sapir, Einav
Mor, Orna
Alroy-Preis, Sharon
Mendelson, Ella
Mandelboim, Michal
Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel
title Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel
title_full Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel
title_fullStr Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel
title_full_unstemmed Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel
title_short Neutralising capacity against Delta (B.1.617.2) and other variants of concern following Comirnaty (BNT162b2, BioNTech/Pfizer) vaccination in health care workers, Israel
title_sort neutralising capacity against delta (b.1.617.2) and other variants of concern following comirnaty (bnt162b2, biontech/pfizer) vaccination in health care workers, israel
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326656/
https://www.ncbi.nlm.nih.gov/pubmed/34212838
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.26.2100557
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