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Retrospective cohort study investigating extent of pertussis transmission during a boarding school outbreak, England, December 2017 to June 2018

On 1 May 2018, a pertussis outbreak was declared and widespread vaccination recommended at an all-female secondary boarding school in southern England. We conducted a retrospective cohort study to determine the extent of pertussis transmission and identify risk factors in this semi-closed population...

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Detalles Bibliográficos
Autores principales: Edmunds, Matt, Mearkle, Rachel, Folliard, Jennifer, Anderson, Charlotte, Balasegaram, Sooria, Chandra, Nastassya, Sawyer, Clare, Fry, Norman K, Ribeiro, Sonia, Palmer, Gemma, Morgan, Michael, Underhill, Gill, Ahmad, Nusreen, Friar, Simon, Charlett, Andre, Litt, David, Brown, Colin S, Amirthalingam, Gayatri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326658/
https://www.ncbi.nlm.nih.gov/pubmed/34212843
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.26.1900736
Descripción
Sumario:On 1 May 2018, a pertussis outbreak was declared and widespread vaccination recommended at an all-female secondary boarding school in southern England. We conducted a retrospective cohort study to determine the extent of pertussis transmission and identify risk factors in this semi-closed population. Of 504 students and staff assessed before post-exposure vaccination, 48% (n = 240) had evidence of pertussis. A sub-analysis of 409 students found that both residential dormitory (p = 0.05) and school year (p = 0.03) were associated with pertussis, with odds decreasing by 11% for each increase in school year (95% confidence interval: 0.7–20.2). Odds of pertussis were 1.7 times higher in those assumed to have received acellular vaccines for their primary course compared with those assumed to have received whole-cell vaccines (based on date of birth), although this difference was not significant (p = 0.12). Our findings support the need for timely, widespread vaccination following identification of cases among adolescents in a semi-closed United Kingdom (UK) setting and to review the evidence for the introduction of an adolescent pertussis booster to the UK routine vaccination programme.