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Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough

OBJECTIVE: Airway sensory nerves involved in the cough reflex are activated by adenosine triphosphate (ATP) agonism of P2X purinoceptor 3 (P2X3) receptors. Transient receptor potential vanilloid 4 (TRPV4) channel activation causes ATP release from airway cells, and it is hypothesised that a TRPV4-AT...

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Detalles Bibliográficos
Autores principales:	Ludbrook, Valerie J., Hanrott, Kate E., Kreindler, James L., Marks-Konczalik, Joanna E., Bird, Nick P., Hewens, Debbie A., Beerahee, Misba, Behm, David J., Morice, Alyn, McGarvey, Lorcan, Parker, Sean M., Birring, Surinder S., Smith, Jaclyn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2021
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326712/ https://www.ncbi.nlm.nih.gov/pubmed/34350286 http://dx.doi.org/10.1183/23120541.00269-2021

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