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Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective

Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable clinical efficacy in treatment of many malignancies especially for B-cell hematologic malignancies. However, the application of CAR-T cells is hampered by potentially adverse events, of which cytokine release syndrome (CRS) is...

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Autores principales: Luan, Chengxin, Zhou, Junjie, Wang, Haixia, Ma, Xiaoyu, Long, Zhangbiao, Cheng, Xin, Chen, Xiaowen, Huang, Zhenqi, Zhang, Dagan, Xia, Ruixiang, Ge, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326907/
https://www.ncbi.nlm.nih.gov/pubmed/34349766
http://dx.doi.org/10.3389/fimmu.2021.707191
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author Luan, Chengxin
Zhou, Junjie
Wang, Haixia
Ma, Xiaoyu
Long, Zhangbiao
Cheng, Xin
Chen, Xiaowen
Huang, Zhenqi
Zhang, Dagan
Xia, Ruixiang
Ge, Jian
author_facet Luan, Chengxin
Zhou, Junjie
Wang, Haixia
Ma, Xiaoyu
Long, Zhangbiao
Cheng, Xin
Chen, Xiaowen
Huang, Zhenqi
Zhang, Dagan
Xia, Ruixiang
Ge, Jian
author_sort Luan, Chengxin
collection PubMed
description Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable clinical efficacy in treatment of many malignancies especially for B-cell hematologic malignancies. However, the application of CAR-T cells is hampered by potentially adverse events, of which cytokine release syndrome (CRS) is one of the severest and the most studied. Local cytokine-release syndrome (L-CRS) at particular parts of the body has been reported once in a while in B-cell lymphoma or other compartmental tumors. The underlying mechanism of L-CRS is not well understood and the existing reports attempting to illustrate it only involve compartmental tumors, some of which even indicated L-CRS only happens in compartmental tumors. Acute lymphoblastic leukemia (ALL) is systemic and our center treated a B-cell ALL patient who exhibited life threatening dyspnea, L-CRS was under suspicion and the patient was successfully rescued with treatment algorithm of CRS. The case is the firstly reported L-CRS related to systemic malignancies and we tentatively propose a model to illustrate the occurrence and development of L-CRS of systemic malignancies inspired by the case and literature, with emphasis on the new recognition of L-CRS.
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spelling pubmed-83269072021-08-03 Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective Luan, Chengxin Zhou, Junjie Wang, Haixia Ma, Xiaoyu Long, Zhangbiao Cheng, Xin Chen, Xiaowen Huang, Zhenqi Zhang, Dagan Xia, Ruixiang Ge, Jian Front Immunol Immunology Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable clinical efficacy in treatment of many malignancies especially for B-cell hematologic malignancies. However, the application of CAR-T cells is hampered by potentially adverse events, of which cytokine release syndrome (CRS) is one of the severest and the most studied. Local cytokine-release syndrome (L-CRS) at particular parts of the body has been reported once in a while in B-cell lymphoma or other compartmental tumors. The underlying mechanism of L-CRS is not well understood and the existing reports attempting to illustrate it only involve compartmental tumors, some of which even indicated L-CRS only happens in compartmental tumors. Acute lymphoblastic leukemia (ALL) is systemic and our center treated a B-cell ALL patient who exhibited life threatening dyspnea, L-CRS was under suspicion and the patient was successfully rescued with treatment algorithm of CRS. The case is the firstly reported L-CRS related to systemic malignancies and we tentatively propose a model to illustrate the occurrence and development of L-CRS of systemic malignancies inspired by the case and literature, with emphasis on the new recognition of L-CRS. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8326907/ /pubmed/34349766 http://dx.doi.org/10.3389/fimmu.2021.707191 Text en Copyright © 2021 Luan, Zhou, Wang, Ma, Long, Cheng, Chen, Huang, Zhang, Xia and Ge https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Luan, Chengxin
Zhou, Junjie
Wang, Haixia
Ma, Xiaoyu
Long, Zhangbiao
Cheng, Xin
Chen, Xiaowen
Huang, Zhenqi
Zhang, Dagan
Xia, Ruixiang
Ge, Jian
Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective
title Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective
title_full Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective
title_fullStr Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective
title_full_unstemmed Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective
title_short Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective
title_sort case report: local cytokine release syndrome in an acute lymphoblastic leukemia patient after treatment with chimeric antigen receptor t-cell therapy: a possible model, literature review and perspective
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326907/
https://www.ncbi.nlm.nih.gov/pubmed/34349766
http://dx.doi.org/10.3389/fimmu.2021.707191
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