Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus

OBJECTIVE: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM). METHODS: This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS). RESULTS: The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS (P<0.001). A nonlinear relationship was discovered between UA and IGF-1 SDS after adjusting for confounding factors. Multivariate piecewise linear regression showed that the levels of IGF-1 SDS increased when UA was <4.17 mg/dl (β 0.12,95% CI −0.04, 0.28; P=0.121) and decreased when UA was >4.17 mg/dl (β −0.38,95% CI −0.64, −0.12; P=0.004). CONCLUSION: This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.