Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study

Sixty-five colistin-resistant Enterobacterales isolates recovered from different clinical specimens were analyzed. The strains were collected in 12 hospitals all over Poland within a period of nine months. Strains were analyzed for eight genes from the mcr family. The presence of mcr-1 gene was dete...

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Autores principales: STEFANIUK, ELŻBIETA M., KOZIŃSKA, ALEKSANDRA, WAŚKO, IZABELA, BARANIAK, ANNA, TYSKI, STEFAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Exeley Inc. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326981/
https://www.ncbi.nlm.nih.gov/pubmed/34349817
http://dx.doi.org/10.33073/pjm-2021-021
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author STEFANIUK, ELŻBIETA M.
KOZIŃSKA, ALEKSANDRA
WAŚKO, IZABELA
BARANIAK, ANNA
TYSKI, STEFAN
author_facet STEFANIUK, ELŻBIETA M.
KOZIŃSKA, ALEKSANDRA
WAŚKO, IZABELA
BARANIAK, ANNA
TYSKI, STEFAN
author_sort STEFANIUK, ELŻBIETA M.
collection PubMed
description Sixty-five colistin-resistant Enterobacterales isolates recovered from different clinical specimens were analyzed. The strains were collected in 12 hospitals all over Poland within a period of nine months. Strains were analyzed for eight genes from the mcr family. The presence of mcr-1 gene was detected in three Escherichia coli strains. The 45/65 isolates were identified as ESBL producers. CTX-M-1-like enzymes were the most common ESBLs (n = 40). One E. coli and seven Klebsiella pneumoniae strains produced carbapenemases, with the NDM being produced by five isolates. Among all the strains tested, four and five were resistant to new drugs meropenem/vaborbactam and ceftazidime/avibactam, respectively.
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spelling pubmed-83269812021-08-03 Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study STEFANIUK, ELŻBIETA M. KOZIŃSKA, ALEKSANDRA WAŚKO, IZABELA BARANIAK, ANNA TYSKI, STEFAN Pol J Microbiol Microbiology Sixty-five colistin-resistant Enterobacterales isolates recovered from different clinical specimens were analyzed. The strains were collected in 12 hospitals all over Poland within a period of nine months. Strains were analyzed for eight genes from the mcr family. The presence of mcr-1 gene was detected in three Escherichia coli strains. The 45/65 isolates were identified as ESBL producers. CTX-M-1-like enzymes were the most common ESBLs (n = 40). One E. coli and seven Klebsiella pneumoniae strains produced carbapenemases, with the NDM being produced by five isolates. Among all the strains tested, four and five were resistant to new drugs meropenem/vaborbactam and ceftazidime/avibactam, respectively. Exeley Inc. 2021-06 2021-06-21 /pmc/articles/PMC8326981/ /pubmed/34349817 http://dx.doi.org/10.33073/pjm-2021-021 Text en © 2021 Elżbieta M. Stefaniuk et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Microbiology
STEFANIUK, ELŻBIETA M.
KOZIŃSKA, ALEKSANDRA
WAŚKO, IZABELA
BARANIAK, ANNA
TYSKI, STEFAN
Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study
title Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study
title_full Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study
title_fullStr Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study
title_full_unstemmed Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study
title_short Occurrence of Beta-Lactamases in Colistin-Resistant Enterobacterales Strains in Poland – a Pilot Study
title_sort occurrence of beta-lactamases in colistin-resistant enterobacterales strains in poland – a pilot study
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326981/
https://www.ncbi.nlm.nih.gov/pubmed/34349817
http://dx.doi.org/10.33073/pjm-2021-021
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