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Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis

In recent years, a rising number of studies have confirmed that microRNA (miRNA) plays a prominent role in the early diagnosis and prognostic value assessment of cardiovascular diseases. The current study was conducted to examine the expression of miR-675-3p in atherosclerosis (AS) patients and to e...

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Autores principales: Wang, Shuangquan, Shao, Wei, Gao, Yang, Zhao, Hongwei, Du, Deyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327005/
https://www.ncbi.nlm.nih.gov/pubmed/34320871
http://dx.doi.org/10.1177/10760296211024754
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author Wang, Shuangquan
Shao, Wei
Gao, Yang
Zhao, Hongwei
Du, Deyong
author_facet Wang, Shuangquan
Shao, Wei
Gao, Yang
Zhao, Hongwei
Du, Deyong
author_sort Wang, Shuangquan
collection PubMed
description In recent years, a rising number of studies have confirmed that microRNA (miRNA) plays a prominent role in the early diagnosis and prognostic value assessment of cardiovascular diseases. The current study was conducted to examine the expression of miR-675-3p in atherosclerosis (AS) patients and to evaluate its clinical diagnosis and prognostic value. 110 AS patients and 70 healthy controls were included in the study. Serum miR-675-3p levels were detected by quantitative real-time PCR (qRT-PCR). The clinical diagnostic significance of serum miR-675-3p in AS patients were investigated by the receiver operating characteristic (ROC) curve. The correlation between miRNA and carotid intima-media thickness (CIMT) was analyzed by the Spearman correlation coefficient. The prognostic significance of serum miR-675-3p was evaluated by the Kaplan-Meier method and Cox regression analysis. The patient’s serum miR-675-3p was significantly increased than the healthy individuals (P < 0.05). An increase of carotid intima-media thickness (CIMT) was positively correlated with the promotion of serum miR-675-3p levels. The area under the ROC curve (AUC) was 0.918, with high sensitivity and specificity. miR-675-3p is a key independent predictor of cardiovascular adverse events in AS patients (HR = 5.375, 95%CI = 1.590-18.170, P = 0.007), and patients with elevated miR-675-3p were more likely to have cardiovascular adverse events (log-rank P = 0.030). Increased miR-675-3p can be used as a potential marker for the diagnosis of AS, and was associated with the poor prognosis of AS.
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spelling pubmed-83270052021-08-09 Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis Wang, Shuangquan Shao, Wei Gao, Yang Zhao, Hongwei Du, Deyong Clin Appl Thromb Hemost Original Manuscript In recent years, a rising number of studies have confirmed that microRNA (miRNA) plays a prominent role in the early diagnosis and prognostic value assessment of cardiovascular diseases. The current study was conducted to examine the expression of miR-675-3p in atherosclerosis (AS) patients and to evaluate its clinical diagnosis and prognostic value. 110 AS patients and 70 healthy controls were included in the study. Serum miR-675-3p levels were detected by quantitative real-time PCR (qRT-PCR). The clinical diagnostic significance of serum miR-675-3p in AS patients were investigated by the receiver operating characteristic (ROC) curve. The correlation between miRNA and carotid intima-media thickness (CIMT) was analyzed by the Spearman correlation coefficient. The prognostic significance of serum miR-675-3p was evaluated by the Kaplan-Meier method and Cox regression analysis. The patient’s serum miR-675-3p was significantly increased than the healthy individuals (P < 0.05). An increase of carotid intima-media thickness (CIMT) was positively correlated with the promotion of serum miR-675-3p levels. The area under the ROC curve (AUC) was 0.918, with high sensitivity and specificity. miR-675-3p is a key independent predictor of cardiovascular adverse events in AS patients (HR = 5.375, 95%CI = 1.590-18.170, P = 0.007), and patients with elevated miR-675-3p were more likely to have cardiovascular adverse events (log-rank P = 0.030). Increased miR-675-3p can be used as a potential marker for the diagnosis of AS, and was associated with the poor prognosis of AS. SAGE Publications 2021-07-29 /pmc/articles/PMC8327005/ /pubmed/34320871 http://dx.doi.org/10.1177/10760296211024754 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Manuscript
Wang, Shuangquan
Shao, Wei
Gao, Yang
Zhao, Hongwei
Du, Deyong
Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis
title Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis
title_full Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis
title_fullStr Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis
title_full_unstemmed Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis
title_short Diagnostic and Prognostic Significance of miR-675-3p in Patients With Atherosclerosis
title_sort diagnostic and prognostic significance of mir-675-3p in patients with atherosclerosis
topic Original Manuscript
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327005/
https://www.ncbi.nlm.nih.gov/pubmed/34320871
http://dx.doi.org/10.1177/10760296211024754
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