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Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells

Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo. The re...

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Autores principales: Abud, Helen E., Chan, Wing Hei, Jardé, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327171/
https://www.ncbi.nlm.nih.gov/pubmed/34350179
http://dx.doi.org/10.3389/fcell.2021.685665
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author Abud, Helen E.
Chan, Wing Hei
Jardé, Thierry
author_facet Abud, Helen E.
Chan, Wing Hei
Jardé, Thierry
author_sort Abud, Helen E.
collection PubMed
description Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo. The recent identification of diverse stromal cell populations that reside underneath intestinal crypts has enabled the characterization of key growth factor cues supplied by these cells. The nature of these signals and how they are delivered to drive intestinal epithelial development, daily homeostasis and tissue regeneration following injury are being investigated. It is clear that aside from EGF, other ligands of the family, including Neuregulin 1 (NRG1), have distinct roles in supporting the function of intestinal stem cells through the ErbB pathway.
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spelling pubmed-83271712021-08-03 Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells Abud, Helen E. Chan, Wing Hei Jardé, Thierry Front Cell Dev Biol Cell and Developmental Biology Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo. The recent identification of diverse stromal cell populations that reside underneath intestinal crypts has enabled the characterization of key growth factor cues supplied by these cells. The nature of these signals and how they are delivered to drive intestinal epithelial development, daily homeostasis and tissue regeneration following injury are being investigated. It is clear that aside from EGF, other ligands of the family, including Neuregulin 1 (NRG1), have distinct roles in supporting the function of intestinal stem cells through the ErbB pathway. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8327171/ /pubmed/34350179 http://dx.doi.org/10.3389/fcell.2021.685665 Text en Copyright © 2021 Abud, Chan and Jardé. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Abud, Helen E.
Chan, Wing Hei
Jardé, Thierry
Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells
title Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells
title_full Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells
title_fullStr Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells
title_full_unstemmed Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells
title_short Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells
title_sort source and impact of the egf family of ligands on intestinal stem cells
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327171/
https://www.ncbi.nlm.nih.gov/pubmed/34350179
http://dx.doi.org/10.3389/fcell.2021.685665
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