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Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis
BACKGROUND: The mechanisms by which moderate tidal volume ventilation (MTV) exacerbates preexisting lung injury are unclear. We hypothesized that systemic endotoxemia via the gut-lung axis would lead to non-canonical and canonical inflammasome activation and pyroptosis in a two-hit model involving p...
Autores principales: | Jin, Shuqing, Ding, Xibing, Yang, Chenxuan, Li, Wenbo, Deng, Meihong, Liao, Hong, Lv, Xin, Pitt, Bruce R., Billiar, Timothy R., Zhang, Li-Ming, Li, Quan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327178/ https://www.ncbi.nlm.nih.gov/pubmed/34349759 http://dx.doi.org/10.3389/fimmu.2021.693874 |
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