Cargando…
MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway
BACKGROUND: Sorafenib is a kinase inhibitor that is used as a first-line therapy in advanced hepatocellular carcinoma (HCC) patients. However, the existence of sorafenib resistance has limited its therapeutic effect. Through RNA sequencing, we demonstrated that miR-138-1-3p was downregulated in sora...
Autores principales: | Li, Tong-tong, Mou, Jie, Pan, Yao-jie, Huo, Fu-chun, Du, Wen-qi, Liang, Jia, Wang, Yang, Zhang, Lan-sheng, Pei, Dong-sheng |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327419/ https://www.ncbi.nlm.nih.gov/pubmed/34340705 http://dx.doi.org/10.1186/s12929-021-00752-4 |
Ejemplares similares
-
MiR-106a-5p inhibits the cell migration and invasion of renal cell carcinoma through targeting PAK5
por: Pan, Yao-Jie, et al.
Publicado: (2017) -
MicroRNA roles in beta-catenin pathway
por: Huang, Kai, et al.
Publicado: (2010) -
PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo
por: Zhang, Ying-Chun, et al.
Publicado: (2017) -
MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1
por: Zhan, Meng-Na, et al.
Publicado: (2017) -
MicroRNA-138-5p regulates pancreatic cancer cell growth through targeting FOXC1
por: Yu, Chao, et al.
Publicado: (2015)