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MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1

BACKGROUND: Patients with diabetes have an increased risk of nonunion and delayed union of fractures. Macrophages have been shown as a key player in diabetic complications. However, it remains obscure how diabetic milieu affects macrophage-derived exosomes and its implications on osteogenic differen...

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Detalles Bibliográficos
Autores principales: Zhang, Dong, Wu, Yifan, Li, Zonghuan, Chen, Hairen, Huang, Siyuan, Jian, Chao, Yu, Aixi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327443/
https://www.ncbi.nlm.nih.gov/pubmed/34340698
http://dx.doi.org/10.1186/s12951-021-00964-8