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Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine
A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327821/ https://www.ncbi.nlm.nih.gov/pubmed/34330722 http://dx.doi.org/10.1136/bcr-2021-242678 |
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author | Hines, Adam Shen, Janice Gloria Olazagasti, Coral Shams, Shakil |
author_facet | Hines, Adam Shen, Janice Gloria Olazagasti, Coral Shams, Shakil |
author_sort | Hines, Adam |
collection | PubMed |
description | A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day 5 after receiving intravenous steroids and intravenous immunoglobulin to treat her suspected diagnosis of immune thrombocytopenic purpura. Extensive workup for her thrombocytopenia and transaminitis was unremarkable including ruling out infectious, autoimmune and toxic causes. A liver biopsy was unrevealing and her transaminitis was improved on discharge. Although not proven, the temporal relationship of her vaccination with thrombocytopenia and abnormal liver enzymes points towards the Moderna mRNA-1273 SARS-CoV-2 vaccine as the most likely inciting factor. |
format | Online Article Text |
id | pubmed-8327821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-83278212021-08-19 Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine Hines, Adam Shen, Janice Gloria Olazagasti, Coral Shams, Shakil BMJ Case Rep Case Report A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day 5 after receiving intravenous steroids and intravenous immunoglobulin to treat her suspected diagnosis of immune thrombocytopenic purpura. Extensive workup for her thrombocytopenia and transaminitis was unremarkable including ruling out infectious, autoimmune and toxic causes. A liver biopsy was unrevealing and her transaminitis was improved on discharge. Although not proven, the temporal relationship of her vaccination with thrombocytopenia and abnormal liver enzymes points towards the Moderna mRNA-1273 SARS-CoV-2 vaccine as the most likely inciting factor. BMJ Publishing Group 2021-07-30 /pmc/articles/PMC8327821/ /pubmed/34330722 http://dx.doi.org/10.1136/bcr-2021-242678 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. |
spellingShingle | Case Report Hines, Adam Shen, Janice Gloria Olazagasti, Coral Shams, Shakil Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine |
title | Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine |
title_full | Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine |
title_fullStr | Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine |
title_full_unstemmed | Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine |
title_short | Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine |
title_sort | immune thrombocytopenic purpura and acute liver injury after covid-19 vaccine |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327821/ https://www.ncbi.nlm.nih.gov/pubmed/34330722 http://dx.doi.org/10.1136/bcr-2021-242678 |
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