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Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine

A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day...

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Autores principales: Hines, Adam, Shen, Janice Gloria, Olazagasti, Coral, Shams, Shakil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327821/
https://www.ncbi.nlm.nih.gov/pubmed/34330722
http://dx.doi.org/10.1136/bcr-2021-242678
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author Hines, Adam
Shen, Janice Gloria
Olazagasti, Coral
Shams, Shakil
author_facet Hines, Adam
Shen, Janice Gloria
Olazagasti, Coral
Shams, Shakil
author_sort Hines, Adam
collection PubMed
description A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day 5 after receiving intravenous steroids and intravenous immunoglobulin to treat her suspected diagnosis of immune thrombocytopenic purpura. Extensive workup for her thrombocytopenia and transaminitis was unremarkable including ruling out infectious, autoimmune and toxic causes. A liver biopsy was unrevealing and her transaminitis was improved on discharge. Although not proven, the temporal relationship of her vaccination with thrombocytopenia and abnormal liver enzymes points towards the Moderna mRNA-1273 SARS-CoV-2 vaccine as the most likely inciting factor.
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spelling pubmed-83278212021-08-19 Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine Hines, Adam Shen, Janice Gloria Olazagasti, Coral Shams, Shakil BMJ Case Rep Case Report A 26-year-old woman was sent to the emergency room by her primary care physician for a new petechial rash and thrombocytopenia 2 weeks after receiving the Moderna mRNA-1273 SARS-CoV-2 vaccine. Her hospital course was complicated by transaminitis. Her platelet count improved to normal on hospital day 5 after receiving intravenous steroids and intravenous immunoglobulin to treat her suspected diagnosis of immune thrombocytopenic purpura. Extensive workup for her thrombocytopenia and transaminitis was unremarkable including ruling out infectious, autoimmune and toxic causes. A liver biopsy was unrevealing and her transaminitis was improved on discharge. Although not proven, the temporal relationship of her vaccination with thrombocytopenia and abnormal liver enzymes points towards the Moderna mRNA-1273 SARS-CoV-2 vaccine as the most likely inciting factor. BMJ Publishing Group 2021-07-30 /pmc/articles/PMC8327821/ /pubmed/34330722 http://dx.doi.org/10.1136/bcr-2021-242678 Text en © BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. https://bmj.com/coronavirus/usageThis article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.
spellingShingle Case Report
Hines, Adam
Shen, Janice Gloria
Olazagasti, Coral
Shams, Shakil
Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine
title Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine
title_full Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine
title_fullStr Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine
title_full_unstemmed Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine
title_short Immune thrombocytopenic purpura and acute liver injury after COVID-19 vaccine
title_sort immune thrombocytopenic purpura and acute liver injury after covid-19 vaccine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327821/
https://www.ncbi.nlm.nih.gov/pubmed/34330722
http://dx.doi.org/10.1136/bcr-2021-242678
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