Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial

BACKGROUND: Soft-tissue sarcomas (STS) in the extremities and trunk treated with standard-of-care preoperative external beam radiation therapy (EBRT) followed by surgical resection are associated with local and distant relapses. In preclinical studies, oncolytic virotherapy in sarcoma has demonstrat...

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Detalles Bibliográficos
Autores principales: Monga, Varun, Miller, Benjamin J, Tanas, Munir, Boukhar, Sarag, Allen, Bryan, Anderson, Carryn, Stephens, Laura, Hartwig, Stacey, Varga, Steven, Houtman, Jon, Wang, Lei, Zhang, Weizhou, Jaber, Omar, Thomason, Jon, Kuehn, David, Rajput, Maheen, Metz, Catherine, Zamba, K.D., Mott, Sarah, Abanonu, Chinemerem, Bhatia, Sudershan, Milhem, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327848/
https://www.ncbi.nlm.nih.gov/pubmed/34330766
http://dx.doi.org/10.1136/jitc-2021-003119

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