Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms

Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA methylation. Examining the global mechanism of action of HC in th...

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Detalles Bibliográficos
Autores principales: Contreras Castillo, Stephania, Montibus, Bertille, Rocha, Azucena, Duke, Will, von Meyenn, Ferdinand, McLornan, Donal, Harrison, Claire, Mullally, Ann, Schulz, Reiner, Oakey, Rebecca J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327916/
https://www.ncbi.nlm.nih.gov/pubmed/34244229
http://dx.doi.org/10.1101/gr.270066.120

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