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Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis
Recently, more and more works have focused and used extensive resources on atherosclerosis research, which is one of the major causes of death globally. Alongside traditional risk factors, such as hyperlipidemia, smoking, hypertension, obesity, and diabetes, mechanical forces, including shear stress...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328000/ https://www.ncbi.nlm.nih.gov/pubmed/34349540 http://dx.doi.org/10.2147/JIR.S319789 |
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author | Shinge, Shafiu A Umar Zhang, Daifang Achu Muluh, Tobias Nie, Yongmei Yu, Fengxu |
author_facet | Shinge, Shafiu A Umar Zhang, Daifang Achu Muluh, Tobias Nie, Yongmei Yu, Fengxu |
author_sort | Shinge, Shafiu A Umar |
collection | PubMed |
description | Recently, more and more works have focused and used extensive resources on atherosclerosis research, which is one of the major causes of death globally. Alongside traditional risk factors, such as hyperlipidemia, smoking, hypertension, obesity, and diabetes, mechanical forces, including shear stress, pressure and stretches exerted on endothelial cells by flow, is proved to be crucial in atherosclerosis development. Studies have recognized the mechanosensitive Piezo1 channel as a special sensor and transducer of various mechanical forces into biochemical signals, and recent studies report its role in atherosclerosis through different mechanical forces in pressure, stretching and turbulent shear stress. Based on our expertise in this field and considering the recent advancement of atherosclerosis research, we will be focusing on the function of Piezo1 and its involvement in various cellular mechanisms and consequent involvement in the development of atherosclerosis in this review. Also, we will discuss various functions of Piezo1 involvement in atherosclerosis and come up with new mechanistic insight for future research. Based on the recent findings, we suggest Piezo1 as a valid candidate for novel therapeutic innovations, in which deep exploration and translating its findings into the clinic will be a new therapeutic strategy for cardiovascular diseases, particularly atherosclerosis. |
format | Online Article Text |
id | pubmed-8328000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-83280002021-08-03 Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis Shinge, Shafiu A Umar Zhang, Daifang Achu Muluh, Tobias Nie, Yongmei Yu, Fengxu J Inflamm Res Review Recently, more and more works have focused and used extensive resources on atherosclerosis research, which is one of the major causes of death globally. Alongside traditional risk factors, such as hyperlipidemia, smoking, hypertension, obesity, and diabetes, mechanical forces, including shear stress, pressure and stretches exerted on endothelial cells by flow, is proved to be crucial in atherosclerosis development. Studies have recognized the mechanosensitive Piezo1 channel as a special sensor and transducer of various mechanical forces into biochemical signals, and recent studies report its role in atherosclerosis through different mechanical forces in pressure, stretching and turbulent shear stress. Based on our expertise in this field and considering the recent advancement of atherosclerosis research, we will be focusing on the function of Piezo1 and its involvement in various cellular mechanisms and consequent involvement in the development of atherosclerosis in this review. Also, we will discuss various functions of Piezo1 involvement in atherosclerosis and come up with new mechanistic insight for future research. Based on the recent findings, we suggest Piezo1 as a valid candidate for novel therapeutic innovations, in which deep exploration and translating its findings into the clinic will be a new therapeutic strategy for cardiovascular diseases, particularly atherosclerosis. Dove 2021-07-27 /pmc/articles/PMC8328000/ /pubmed/34349540 http://dx.doi.org/10.2147/JIR.S319789 Text en © 2021 Shinge et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Shinge, Shafiu A Umar Zhang, Daifang Achu Muluh, Tobias Nie, Yongmei Yu, Fengxu Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis |
title | Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis |
title_full | Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis |
title_fullStr | Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis |
title_full_unstemmed | Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis |
title_short | Mechanosensitive Piezo1 Channel Evoked-Mechanical Signals in Atherosclerosis |
title_sort | mechanosensitive piezo1 channel evoked-mechanical signals in atherosclerosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328000/ https://www.ncbi.nlm.nih.gov/pubmed/34349540 http://dx.doi.org/10.2147/JIR.S319789 |
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