COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1(+) neutrophils and CD14(+) monocytes

We explored the potential link between chronic inflammatory arthritis and COVID-19 pathogenic and resolving macrophage pathways and their role in COVID-19 pathogenesis. We found that bronchoalveolar lavage fluid (BALF) macrophage clusters FCN1(+) and FCN1(+)SPP1(+) predominant in severe COVID-19 wer...

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Detalles Bibliográficos
Autores principales: MacDonald, Lucy, Alivernini, Stefano, Tolusso, Barbara, Elmesmari, Aziza, Somma, Domenico, Perniola, Simone, Paglionico, Annamaria, Petricca, Luca, Bosello, Silvia L., Carfì, Angelo, Sali, Michela, Stigliano, Egidio, Cingolani, Antonella, Murri, Rita, Arena, Vincenzo, Fantoni, Massimo, Antonelli, Massimo, Landi, Francesco, Franceschi, Francesco, Sanguinetti, Maurizio, McInnes, Iain B., McSharry, Charles, Gasbarrini, Antonio, Otto, Thomas D., Kurowska-Stolarska, Mariola, Gremese, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328085/
https://www.ncbi.nlm.nih.gov/pubmed/34143756
http://dx.doi.org/10.1172/jci.insight.147413

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