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A small-molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase improves obesity, nephropathy and cardiomyopathy in obese ZSF1 rats

Prolyl hydroxylase (PH) enzymes control the degradation of hypoxia-inducible factor (HIF), a transcription factor known to regulate erythropoiesis, angiogenesis, glucose metabolism, cell proliferation, and apoptosis. HIF-PH inhibitors (HIF-PHIs) correct anemia in patients with renal disease and in a...

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Detalles Bibliográficos
Autores principales:	Signore, Pierre E., Guo, Guangjie, Wei, Zhihua, Zhang, Weihua, Lin, Al, del Balzo, Ughetta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328318/ https://www.ncbi.nlm.nih.gov/pubmed/34339435 http://dx.doi.org/10.1371/journal.pone.0255022

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