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Automated Synthesis and Initial Evaluation of (4′-Amino-5′,8′-difluoro-1′H-spiro[piperidine-4,2′-quinazolin]-1-yl)(4-[(18)F]fluorophenyl)methanone for PET/MR Imaging of Inducible Nitric Oxide Synthase

BACKGROUND: Inducible nitric oxide synthase (iNOS) plays a crucial role in neuroinflammation, especially microglial activity, and may potentially represent a useful biomarker of neuroinflammation. In this study, we carefully defined a strategic plan to develop iNOS-targeted molecular PET imaging usi...

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Detalles Bibliográficos
Autores principales:	Yeh, Skye Hsin-Hsien, Huang, Wen-Sheng, Chiu, Chuang-Hsin, Chen, Chuan-Lin, Chen, Hui-Ting, Chi, Dae Yoon, Ge, Zhengxing, Yu, Tsung-Hsun, Wang, Pao-Yeh, Kuo, Yu-Yeh, Hung, Chun-Tse, Li, Geng-Ying, Chang, Chi-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328489/ https://www.ncbi.nlm.nih.gov/pubmed/34381316 http://dx.doi.org/10.1155/2021/9996125

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