Cargando…
The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis
OBJECTIVE: Ischemic preconditioning (IPC) has gradually been promoted in clinical practice to lower the risk of cardiovascular surgery and postoperative complications. We investigated the role of IPC on vascular endothelial function and the relationship between IPC, flow-mediated dilation (FMD), and...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328691/ https://www.ncbi.nlm.nih.gov/pubmed/34349827 http://dx.doi.org/10.1155/2021/6690691 |
_version_ | 1783732344720457728 |
---|---|
author | Gu, Xufang Liu, Zhichao Gao, Shengwei Ma, Li Chen, Jinhong Wang, Zhenxing Lu, Anmin Wang, Zhizhong Wang, Baohe Li, Yuhong |
author_facet | Gu, Xufang Liu, Zhichao Gao, Shengwei Ma, Li Chen, Jinhong Wang, Zhenxing Lu, Anmin Wang, Zhizhong Wang, Baohe Li, Yuhong |
author_sort | Gu, Xufang |
collection | PubMed |
description | OBJECTIVE: Ischemic preconditioning (IPC) has gradually been promoted in clinical practice to lower the risk of cardiovascular surgery and postoperative complications. We investigated the role of IPC on vascular endothelial function and the relationship between IPC, flow-mediated dilation (FMD), and brachial artery diameter (BAD). METHODS: Systematic searches were conducted in PubMed, Medline, Cochrane Library, Embase, and Scopus databases from their inception to March 20, 2020. This research included randomized controlled trials (RCTs) with adults, and the values of FMD and BAD were considered as the primary outcomes. Ten studies comprising 292 participants were included in the meta-analysis. RESULTS: Regarding FMD, we observed beneficial effects of IPC on endothelial function (standardized mean difference (SMD): 1.82; 95% confidence interval (CI): 0.64, 3.01; p < 0.001; I(2) = 89.9%). However, the available evidence did not indicate that IPC affected BAD (SMD: 0.08; 95% CI: −0.03, 0.18; p > 0.05; I(2) = 76.5%). CONCLUSIONS: Our meta-analysis indicated a significant effect of IPC on the endothelial function of the blood vessels, affecting FMD but not BAD. |
format | Online Article Text |
id | pubmed-8328691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83286912021-08-03 The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis Gu, Xufang Liu, Zhichao Gao, Shengwei Ma, Li Chen, Jinhong Wang, Zhenxing Lu, Anmin Wang, Zhizhong Wang, Baohe Li, Yuhong Evid Based Complement Alternat Med Review Article OBJECTIVE: Ischemic preconditioning (IPC) has gradually been promoted in clinical practice to lower the risk of cardiovascular surgery and postoperative complications. We investigated the role of IPC on vascular endothelial function and the relationship between IPC, flow-mediated dilation (FMD), and brachial artery diameter (BAD). METHODS: Systematic searches were conducted in PubMed, Medline, Cochrane Library, Embase, and Scopus databases from their inception to March 20, 2020. This research included randomized controlled trials (RCTs) with adults, and the values of FMD and BAD were considered as the primary outcomes. Ten studies comprising 292 participants were included in the meta-analysis. RESULTS: Regarding FMD, we observed beneficial effects of IPC on endothelial function (standardized mean difference (SMD): 1.82; 95% confidence interval (CI): 0.64, 3.01; p < 0.001; I(2) = 89.9%). However, the available evidence did not indicate that IPC affected BAD (SMD: 0.08; 95% CI: −0.03, 0.18; p > 0.05; I(2) = 76.5%). CONCLUSIONS: Our meta-analysis indicated a significant effect of IPC on the endothelial function of the blood vessels, affecting FMD but not BAD. Hindawi 2021-07-26 /pmc/articles/PMC8328691/ /pubmed/34349827 http://dx.doi.org/10.1155/2021/6690691 Text en Copyright © 2021 Xufang Gu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gu, Xufang Liu, Zhichao Gao, Shengwei Ma, Li Chen, Jinhong Wang, Zhenxing Lu, Anmin Wang, Zhizhong Wang, Baohe Li, Yuhong The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis |
title | The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis |
title_full | The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis |
title_fullStr | The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis |
title_full_unstemmed | The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis |
title_short | The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis |
title_sort | effects of ischemic preconditioning supplementation on endothelial function: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328691/ https://www.ncbi.nlm.nih.gov/pubmed/34349827 http://dx.doi.org/10.1155/2021/6690691 |
work_keys_str_mv | AT guxufang theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT liuzhichao theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT gaoshengwei theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT mali theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT chenjinhong theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT wangzhenxing theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT luanmin theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT wangzhizhong theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT wangbaohe theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT liyuhong theeffectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT guxufang effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT liuzhichao effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT gaoshengwei effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT mali effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT chenjinhong effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT wangzhenxing effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT luanmin effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT wangzhizhong effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT wangbaohe effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis AT liyuhong effectsofischemicpreconditioningsupplementationonendothelialfunctionasystematicreviewandmetaanalysis |