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The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis

OBJECTIVE: Ischemic preconditioning (IPC) has gradually been promoted in clinical practice to lower the risk of cardiovascular surgery and postoperative complications. We investigated the role of IPC on vascular endothelial function and the relationship between IPC, flow-mediated dilation (FMD), and...

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Autores principales: Gu, Xufang, Liu, Zhichao, Gao, Shengwei, Ma, Li, Chen, Jinhong, Wang, Zhenxing, Lu, Anmin, Wang, Zhizhong, Wang, Baohe, Li, Yuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328691/
https://www.ncbi.nlm.nih.gov/pubmed/34349827
http://dx.doi.org/10.1155/2021/6690691
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author Gu, Xufang
Liu, Zhichao
Gao, Shengwei
Ma, Li
Chen, Jinhong
Wang, Zhenxing
Lu, Anmin
Wang, Zhizhong
Wang, Baohe
Li, Yuhong
author_facet Gu, Xufang
Liu, Zhichao
Gao, Shengwei
Ma, Li
Chen, Jinhong
Wang, Zhenxing
Lu, Anmin
Wang, Zhizhong
Wang, Baohe
Li, Yuhong
author_sort Gu, Xufang
collection PubMed
description OBJECTIVE: Ischemic preconditioning (IPC) has gradually been promoted in clinical practice to lower the risk of cardiovascular surgery and postoperative complications. We investigated the role of IPC on vascular endothelial function and the relationship between IPC, flow-mediated dilation (FMD), and brachial artery diameter (BAD). METHODS: Systematic searches were conducted in PubMed, Medline, Cochrane Library, Embase, and Scopus databases from their inception to March 20, 2020. This research included randomized controlled trials (RCTs) with adults, and the values of FMD and BAD were considered as the primary outcomes. Ten studies comprising 292 participants were included in the meta-analysis. RESULTS: Regarding FMD, we observed beneficial effects of IPC on endothelial function (standardized mean difference (SMD): 1.82; 95% confidence interval (CI): 0.64, 3.01; p < 0.001; I(2) = 89.9%). However, the available evidence did not indicate that IPC affected BAD (SMD: 0.08; 95% CI: −0.03, 0.18; p > 0.05; I(2) = 76.5%). CONCLUSIONS: Our meta-analysis indicated a significant effect of IPC on the endothelial function of the blood vessels, affecting FMD but not BAD.
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spelling pubmed-83286912021-08-03 The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis Gu, Xufang Liu, Zhichao Gao, Shengwei Ma, Li Chen, Jinhong Wang, Zhenxing Lu, Anmin Wang, Zhizhong Wang, Baohe Li, Yuhong Evid Based Complement Alternat Med Review Article OBJECTIVE: Ischemic preconditioning (IPC) has gradually been promoted in clinical practice to lower the risk of cardiovascular surgery and postoperative complications. We investigated the role of IPC on vascular endothelial function and the relationship between IPC, flow-mediated dilation (FMD), and brachial artery diameter (BAD). METHODS: Systematic searches were conducted in PubMed, Medline, Cochrane Library, Embase, and Scopus databases from their inception to March 20, 2020. This research included randomized controlled trials (RCTs) with adults, and the values of FMD and BAD were considered as the primary outcomes. Ten studies comprising 292 participants were included in the meta-analysis. RESULTS: Regarding FMD, we observed beneficial effects of IPC on endothelial function (standardized mean difference (SMD): 1.82; 95% confidence interval (CI): 0.64, 3.01; p < 0.001; I(2) = 89.9%). However, the available evidence did not indicate that IPC affected BAD (SMD: 0.08; 95% CI: −0.03, 0.18; p > 0.05; I(2) = 76.5%). CONCLUSIONS: Our meta-analysis indicated a significant effect of IPC on the endothelial function of the blood vessels, affecting FMD but not BAD. Hindawi 2021-07-26 /pmc/articles/PMC8328691/ /pubmed/34349827 http://dx.doi.org/10.1155/2021/6690691 Text en Copyright © 2021 Xufang Gu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gu, Xufang
Liu, Zhichao
Gao, Shengwei
Ma, Li
Chen, Jinhong
Wang, Zhenxing
Lu, Anmin
Wang, Zhizhong
Wang, Baohe
Li, Yuhong
The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis
title The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis
title_full The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis
title_fullStr The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis
title_full_unstemmed The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis
title_short The Effects of Ischemic Preconditioning Supplementation on Endothelial Function: A Systematic Review and Meta-Analysis
title_sort effects of ischemic preconditioning supplementation on endothelial function: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328691/
https://www.ncbi.nlm.nih.gov/pubmed/34349827
http://dx.doi.org/10.1155/2021/6690691
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