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The Effects of Mesenchymal Stem Cell on Colorectal Cancer
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with nonobvious early symptoms and late symptoms of anemia, weight loss, and other systemic symptoms. Its morbidity and fatality rate are next only to gastric cancer, esophageal cancer, and primary liver cancer among d...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328693/ https://www.ncbi.nlm.nih.gov/pubmed/34349805 http://dx.doi.org/10.1155/2021/9136583 |
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author | Yuan, Jintao Wei, Zhiping Xu, Xinwei Ocansey, Dickson Kofi Wiredu Cai, Xiu Mao, Fei |
author_facet | Yuan, Jintao Wei, Zhiping Xu, Xinwei Ocansey, Dickson Kofi Wiredu Cai, Xiu Mao, Fei |
author_sort | Yuan, Jintao |
collection | PubMed |
description | Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with nonobvious early symptoms and late symptoms of anemia, weight loss, and other systemic symptoms. Its morbidity and fatality rate are next only to gastric cancer, esophageal cancer, and primary liver cancer among digestive malignancies. In addition to the conventional surgical intervention, other therapies such as radiotherapy and chemotherapy and new treatment methods such as biologics and microbiological products have been introduced. As a promising cell therapy, mesenchymal stem cell (MSC) has attracted extensive research attention. MSCs are early undifferentiated pluripotent stem cells, which have the common features of stem cells, including self-replication, self-division, self-renewal, and multidirectional differentiation. MSCs come from a wide range of sources and can be extracted from a variety of tissues such as the bone marrow, umbilical cord, and fat. Current studies have shown that MSCs have a variety of biological functions such as immune regulation, tissue damage repair, and therapeutic effects on tumors such as CRC. This review outlines the overview of MSCs and CRC and summarizes the role of MSC application in CRC. |
format | Online Article Text |
id | pubmed-8328693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83286932021-08-03 The Effects of Mesenchymal Stem Cell on Colorectal Cancer Yuan, Jintao Wei, Zhiping Xu, Xinwei Ocansey, Dickson Kofi Wiredu Cai, Xiu Mao, Fei Stem Cells Int Review Article Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with nonobvious early symptoms and late symptoms of anemia, weight loss, and other systemic symptoms. Its morbidity and fatality rate are next only to gastric cancer, esophageal cancer, and primary liver cancer among digestive malignancies. In addition to the conventional surgical intervention, other therapies such as radiotherapy and chemotherapy and new treatment methods such as biologics and microbiological products have been introduced. As a promising cell therapy, mesenchymal stem cell (MSC) has attracted extensive research attention. MSCs are early undifferentiated pluripotent stem cells, which have the common features of stem cells, including self-replication, self-division, self-renewal, and multidirectional differentiation. MSCs come from a wide range of sources and can be extracted from a variety of tissues such as the bone marrow, umbilical cord, and fat. Current studies have shown that MSCs have a variety of biological functions such as immune regulation, tissue damage repair, and therapeutic effects on tumors such as CRC. This review outlines the overview of MSCs and CRC and summarizes the role of MSC application in CRC. Hindawi 2021-07-24 /pmc/articles/PMC8328693/ /pubmed/34349805 http://dx.doi.org/10.1155/2021/9136583 Text en Copyright © 2021 Jintao Yuan et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yuan, Jintao Wei, Zhiping Xu, Xinwei Ocansey, Dickson Kofi Wiredu Cai, Xiu Mao, Fei The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
title | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
title_full | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
title_fullStr | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
title_full_unstemmed | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
title_short | The Effects of Mesenchymal Stem Cell on Colorectal Cancer |
title_sort | effects of mesenchymal stem cell on colorectal cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328693/ https://www.ncbi.nlm.nih.gov/pubmed/34349805 http://dx.doi.org/10.1155/2021/9136583 |
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