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Inflammation induces zebrafish regeneration
Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism. Upon damage, mammals can only efficiently restore a few tissues including the liver, skin, epithelia of the lung, kidney, and gut. In contrast, lower vertebrates such as zebrafish...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328752/ https://www.ncbi.nlm.nih.gov/pubmed/33510057 http://dx.doi.org/10.4103/1673-5374.306059 |
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author | Iribarne, Maria |
author_facet | Iribarne, Maria |
author_sort | Iribarne, Maria |
collection | PubMed |
description | Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism. Upon damage, mammals can only efficiently restore a few tissues including the liver, skin, epithelia of the lung, kidney, and gut. In contrast, lower vertebrates such as zebrafish possess an extraordinary regeneration ability, which restores the normal function of a broad spectrum of tissues including heart, fin, brain, spinal cord, and retina. This regeneration process is either mediated by the proliferation of resident stem cells, or cells that dedifferentiate into a stem cell-like. In recent years, evidence has suggested that the innate immune system can modulate stem cell activity to initiate the regenerative response to damage. This review will explore some of the newer concepts of inflammation in zebrafish regeneration in different tissues. Understanding how inflammation regulates regeneration in zebrafish would provide important clues to improve the therapeutic strategies for repairing injured mammalian tissues that do not have an inherent regenerative capacity. |
format | Online Article Text |
id | pubmed-8328752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-83287522021-08-09 Inflammation induces zebrafish regeneration Iribarne, Maria Neural Regen Res Invited Review Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism. Upon damage, mammals can only efficiently restore a few tissues including the liver, skin, epithelia of the lung, kidney, and gut. In contrast, lower vertebrates such as zebrafish possess an extraordinary regeneration ability, which restores the normal function of a broad spectrum of tissues including heart, fin, brain, spinal cord, and retina. This regeneration process is either mediated by the proliferation of resident stem cells, or cells that dedifferentiate into a stem cell-like. In recent years, evidence has suggested that the innate immune system can modulate stem cell activity to initiate the regenerative response to damage. This review will explore some of the newer concepts of inflammation in zebrafish regeneration in different tissues. Understanding how inflammation regulates regeneration in zebrafish would provide important clues to improve the therapeutic strategies for repairing injured mammalian tissues that do not have an inherent regenerative capacity. Wolters Kluwer - Medknow 2021-01-25 /pmc/articles/PMC8328752/ /pubmed/33510057 http://dx.doi.org/10.4103/1673-5374.306059 Text en Copyright: © 2021 Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Iribarne, Maria Inflammation induces zebrafish regeneration |
title | Inflammation induces zebrafish regeneration |
title_full | Inflammation induces zebrafish regeneration |
title_fullStr | Inflammation induces zebrafish regeneration |
title_full_unstemmed | Inflammation induces zebrafish regeneration |
title_short | Inflammation induces zebrafish regeneration |
title_sort | inflammation induces zebrafish regeneration |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328752/ https://www.ncbi.nlm.nih.gov/pubmed/33510057 http://dx.doi.org/10.4103/1673-5374.306059 |
work_keys_str_mv | AT iribarnemaria inflammationinduceszebrafishregeneration |