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Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia

While vaccination is the single most effective intervention to drastically reduce severe disease and death following SARS-CoV-2 infection, as shown in UK and Israel, some serious concerns have been raised for an unusual adverse drug reaction (ADR), including vaccine-induced immune thrombotic thrombo...

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Autores principales: Mauriello, Alessandro, Scimeca, Manuel, Amelio, Ivano, Massoud, Renato, Novelli, Antonio, Di Lorenzo, Francesca, Finocchiaro, Susanna, Cimino, Carolina, Telesca, Rossana, Chiocchi, Marcello, Sun, Qiang, Wang, Ying, Shi, Yufang, Novelli, Giuseppe, Melino, Gerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328816/
https://www.ncbi.nlm.nih.gov/pubmed/34344867
http://dx.doi.org/10.1038/s41419-021-04058-z
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author Mauriello, Alessandro
Scimeca, Manuel
Amelio, Ivano
Massoud, Renato
Novelli, Antonio
Di Lorenzo, Francesca
Finocchiaro, Susanna
Cimino, Carolina
Telesca, Rossana
Chiocchi, Marcello
Sun, Qiang
Wang, Ying
Shi, Yufang
Novelli, Giuseppe
Melino, Gerry
author_facet Mauriello, Alessandro
Scimeca, Manuel
Amelio, Ivano
Massoud, Renato
Novelli, Antonio
Di Lorenzo, Francesca
Finocchiaro, Susanna
Cimino, Carolina
Telesca, Rossana
Chiocchi, Marcello
Sun, Qiang
Wang, Ying
Shi, Yufang
Novelli, Giuseppe
Melino, Gerry
author_sort Mauriello, Alessandro
collection PubMed
description While vaccination is the single most effective intervention to drastically reduce severe disease and death following SARS-CoV-2 infection, as shown in UK and Israel, some serious concerns have been raised for an unusual adverse drug reaction (ADR), including vaccine-induced immune thrombotic thrombocytopenia (VITT) with concurrent low platelets as well as capillary leak syndrome. In fact, the overall safety of the vaccine is highlighted by the low frequency of ADR considering that in UK, by the early June, 40 million first doses and 29 million second doses have been injected; nonetheless, 390 thrombotic events, including 71 fatal events have been reported. Interestingly, the cases reported low platelet counts with the presence of anti-platelet factor-4 (PF4) antibodies, indicating an abnormal clotting reaction. Here, out of three referred cases, we report a post-vaccine clinical case of fatal thrombosis with postmortem examination and whole exome sequencing (WES) analysis, whose pathogenesis appeared associated to a preexisting condition of thrombocytopenia due to myelodysplasia.
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spelling pubmed-83288162021-08-03 Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia Mauriello, Alessandro Scimeca, Manuel Amelio, Ivano Massoud, Renato Novelli, Antonio Di Lorenzo, Francesca Finocchiaro, Susanna Cimino, Carolina Telesca, Rossana Chiocchi, Marcello Sun, Qiang Wang, Ying Shi, Yufang Novelli, Giuseppe Melino, Gerry Cell Death Dis Article While vaccination is the single most effective intervention to drastically reduce severe disease and death following SARS-CoV-2 infection, as shown in UK and Israel, some serious concerns have been raised for an unusual adverse drug reaction (ADR), including vaccine-induced immune thrombotic thrombocytopenia (VITT) with concurrent low platelets as well as capillary leak syndrome. In fact, the overall safety of the vaccine is highlighted by the low frequency of ADR considering that in UK, by the early June, 40 million first doses and 29 million second doses have been injected; nonetheless, 390 thrombotic events, including 71 fatal events have been reported. Interestingly, the cases reported low platelet counts with the presence of anti-platelet factor-4 (PF4) antibodies, indicating an abnormal clotting reaction. Here, out of three referred cases, we report a post-vaccine clinical case of fatal thrombosis with postmortem examination and whole exome sequencing (WES) analysis, whose pathogenesis appeared associated to a preexisting condition of thrombocytopenia due to myelodysplasia. Nature Publishing Group UK 2021-08-03 /pmc/articles/PMC8328816/ /pubmed/34344867 http://dx.doi.org/10.1038/s41419-021-04058-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Mauriello, Alessandro
Scimeca, Manuel
Amelio, Ivano
Massoud, Renato
Novelli, Antonio
Di Lorenzo, Francesca
Finocchiaro, Susanna
Cimino, Carolina
Telesca, Rossana
Chiocchi, Marcello
Sun, Qiang
Wang, Ying
Shi, Yufang
Novelli, Giuseppe
Melino, Gerry
Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia
title Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia
title_full Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia
title_fullStr Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia
title_full_unstemmed Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia
title_short Thromboembolism after COVID-19 vaccine in patients with preexisting thrombocytopenia
title_sort thromboembolism after covid-19 vaccine in patients with preexisting thrombocytopenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328816/
https://www.ncbi.nlm.nih.gov/pubmed/34344867
http://dx.doi.org/10.1038/s41419-021-04058-z
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