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Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends

Giant cell tumor (GCT) is classically described as a locally aggressive, epiphyseo-metaphyseal osteolytic tumor occurring in young adults. They are mostly seen in long bones while some are also found in the iliac bone and spine and a very small proportion occurs in hand bones. Due to the rarity of G...

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Autores principales: Agrawal, Alok C, Verma, Shilp, Kar, Bikram, Sakale, Harshal, Choudhary, Ranjeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328844/
https://www.ncbi.nlm.nih.gov/pubmed/34354887
http://dx.doi.org/10.7759/cureus.16150
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author Agrawal, Alok C
Verma, Shilp
Kar, Bikram
Sakale, Harshal
Choudhary, Ranjeet
author_facet Agrawal, Alok C
Verma, Shilp
Kar, Bikram
Sakale, Harshal
Choudhary, Ranjeet
author_sort Agrawal, Alok C
collection PubMed
description Giant cell tumor (GCT) is classically described as a locally aggressive, epiphyseo-metaphyseal osteolytic tumor occurring in young adults. They are mostly seen in long bones while some are also found in the iliac bone and spine and a very small proportion occurs in hand bones. Due to the rarity of GCT in metacarpal, there is a paucity of treatment options available. In an extensive literature search on PubMed, Embase, Medline, and Ovid from 2004 till date, very few cases were reported. The various treatment options available are intralesional curettage with or without adjuvant therapy, wide resection, free osteoarticular metatarsal transfer, and, occasionally, ray amputation may also be done. After simple curettage, a reasonably high recurrence rate also imposes comprehensive en-bloc excision, but still, there are many case reports of recurrence. Experience with a case of GCT of the whole first metacarpal extending from the carpometacarpal to the metacarpophalangeal joint is not thoroughly described in the literature. We hereby report a mammoth GCT of the first metacarpal treated by excision and reconstruction by free fibular graft and adjacent joint fusion with an excellent functional outcome at one-year follow-up.
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spelling pubmed-83288442021-08-04 Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends Agrawal, Alok C Verma, Shilp Kar, Bikram Sakale, Harshal Choudhary, Ranjeet Cureus Oncology Giant cell tumor (GCT) is classically described as a locally aggressive, epiphyseo-metaphyseal osteolytic tumor occurring in young adults. They are mostly seen in long bones while some are also found in the iliac bone and spine and a very small proportion occurs in hand bones. Due to the rarity of GCT in metacarpal, there is a paucity of treatment options available. In an extensive literature search on PubMed, Embase, Medline, and Ovid from 2004 till date, very few cases were reported. The various treatment options available are intralesional curettage with or without adjuvant therapy, wide resection, free osteoarticular metatarsal transfer, and, occasionally, ray amputation may also be done. After simple curettage, a reasonably high recurrence rate also imposes comprehensive en-bloc excision, but still, there are many case reports of recurrence. Experience with a case of GCT of the whole first metacarpal extending from the carpometacarpal to the metacarpophalangeal joint is not thoroughly described in the literature. We hereby report a mammoth GCT of the first metacarpal treated by excision and reconstruction by free fibular graft and adjacent joint fusion with an excellent functional outcome at one-year follow-up. Cureus 2021-07-03 /pmc/articles/PMC8328844/ /pubmed/34354887 http://dx.doi.org/10.7759/cureus.16150 Text en Copyright © 2021, Agrawal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Agrawal, Alok C
Verma, Shilp
Kar, Bikram
Sakale, Harshal
Choudhary, Ranjeet
Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends
title Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends
title_full Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends
title_fullStr Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends
title_full_unstemmed Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends
title_short Mammoth Giant Cell Tumor of the First Metacarpal: A Case Report and Management Trends
title_sort mammoth giant cell tumor of the first metacarpal: a case report and management trends
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328844/
https://www.ncbi.nlm.nih.gov/pubmed/34354887
http://dx.doi.org/10.7759/cureus.16150
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