Edible fruit extracts and fruit juices as potential source of antiviral agents: a review

Fruits have been widely consumed since the beginning of human evolution and are important source of a healthy being and helpful in treating various diseases as immunity boosters with the presence of a rich amount of health-promoting bioactives. Therapeutic efficacies of fruit extracts are reported to have immune-modulatory properties and influence greatly on the immune system of human body. Given the facts of the efficacy of edible fruits in improving the immunity of body as immune-stimulants, we have tried to consolidate the previously published data on edible fruits and its juices with antiviral potential. The objective of this review was to gather information on edible fruits with antiviral properties and the efforts to obtain their efficient delivery. Online bibliographical databases like PubMed, Scopus, and Web of Science were used to search literature on the antiviral effect of edible fruit extracts and fruit juices. The edible fruits like almond, apple, bael, blackberry, black currants, crane berry, citrus, grapes, Japanese cherry, mango, mulberry, pistachios, pomegranate, and strawberry showed promising antiviral properties against the different pathogenic viruses. The review provided an overview of likely effects of the intake of edible fruit extracts/fruit juices to strengthen the immune cells by reducing the oxidative stress in host body system which in turn inhibits the viral attachment and replication on the host cell. Hence these fruits can also be exploited in combating COVID-19 in the current pandemic situation. To validate the present hypothesis, the proposed edible fruit extracts can be evaluated against the SARS-CoV-2 via in vitro and in vivo models to confirm the fact.