Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine

The development of liver metastases in colon rectal cancer has a strong impact on the overall survival (OS) of the patient, with a 5-year survival rate of 5% with palliative treatment. Surgical resection combined with pharmacological treatment can achieve a 5-year OS rate of 31–58%. However, in only...

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Autores principales: Finotti, Michele, Vitale, Alessandro, Gringeri, Enrico, D'Amico, Francesco Enrico, Boetto, Riccardo, Bertacco, Alessandra, Lonardi, Sara, Bergamo, Francesca, Feltracco, Paolo, Cillo, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329096/
https://www.ncbi.nlm.nih.gov/pubmed/34355016
http://dx.doi.org/10.3389/fsurg.2021.693387
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author Finotti, Michele
Vitale, Alessandro
Gringeri, Enrico
D'Amico, Francesco Enrico
Boetto, Riccardo
Bertacco, Alessandra
Lonardi, Sara
Bergamo, Francesca
Feltracco, Paolo
Cillo, Umberto
author_facet Finotti, Michele
Vitale, Alessandro
Gringeri, Enrico
D'Amico, Francesco Enrico
Boetto, Riccardo
Bertacco, Alessandra
Lonardi, Sara
Bergamo, Francesca
Feltracco, Paolo
Cillo, Umberto
author_sort Finotti, Michele
collection PubMed
description The development of liver metastases in colon rectal cancer has a strong impact on the overall survival (OS) of the patient, with a 5-year survival rate of 5% with palliative treatment. Surgical resection combined with pharmacological treatment can achieve a 5-year OS rate of 31–58%. However, in only 20% of patients with colon rectal liver metastases (CRLMs), liver resection is feasible. In highly selected patients, recent trials and studies proved that liver transplantation (LT) for non-resectable CRLM is a surgical option with an excellent long-term OS. The paper aims to review the indications and outcome of LT for CRLMs, with a special focus on immunosuppressive therapy and the management of local and extrahepatic recurrence after LT.
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spelling pubmed-83290962021-08-04 Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine Finotti, Michele Vitale, Alessandro Gringeri, Enrico D'Amico, Francesco Enrico Boetto, Riccardo Bertacco, Alessandra Lonardi, Sara Bergamo, Francesca Feltracco, Paolo Cillo, Umberto Front Surg Surgery The development of liver metastases in colon rectal cancer has a strong impact on the overall survival (OS) of the patient, with a 5-year survival rate of 5% with palliative treatment. Surgical resection combined with pharmacological treatment can achieve a 5-year OS rate of 31–58%. However, in only 20% of patients with colon rectal liver metastases (CRLMs), liver resection is feasible. In highly selected patients, recent trials and studies proved that liver transplantation (LT) for non-resectable CRLM is a surgical option with an excellent long-term OS. The paper aims to review the indications and outcome of LT for CRLMs, with a special focus on immunosuppressive therapy and the management of local and extrahepatic recurrence after LT. Frontiers Media S.A. 2021-07-20 /pmc/articles/PMC8329096/ /pubmed/34355016 http://dx.doi.org/10.3389/fsurg.2021.693387 Text en Copyright © 2021 Finotti, Vitale, Gringeri, D'Amico, Boetto, Bertacco, Lonardi, Bergamo, Feltracco and Cillo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Finotti, Michele
Vitale, Alessandro
Gringeri, Enrico
D'Amico, Francesco Enrico
Boetto, Riccardo
Bertacco, Alessandra
Lonardi, Sara
Bergamo, Francesca
Feltracco, Paolo
Cillo, Umberto
Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine
title Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine
title_full Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine
title_fullStr Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine
title_full_unstemmed Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine
title_short Colon Rectal Liver Metastases: The Role of the Liver Transplantation in the Era of the Transplant Oncology and Precision Medicine
title_sort colon rectal liver metastases: the role of the liver transplantation in the era of the transplant oncology and precision medicine
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329096/
https://www.ncbi.nlm.nih.gov/pubmed/34355016
http://dx.doi.org/10.3389/fsurg.2021.693387
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