Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein

This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in photoreceptors. The main focus is on how the fluctuations of free calcium concentrations in photoreceptors between light and dark regulate the activity of retinal...

Descripción completa

Detalles Bibliográficos
Autores principales: Dizhoor, Alexander M., Peshenko, Igor V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329130/
https://www.ncbi.nlm.nih.gov/pubmed/33537894
http://dx.doi.org/10.1007/s00424-021-02523-4
_version_ 1783732434718687232
author Dizhoor, Alexander M.
Peshenko, Igor V.
author_facet Dizhoor, Alexander M.
Peshenko, Igor V.
author_sort Dizhoor, Alexander M.
collection PubMed
description This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in photoreceptors. The main focus is on how the fluctuations of free calcium concentrations in photoreceptors between light and dark regulate the activity of retinal membrane guanylyl cyclase (RetGC) via calcium sensor proteins. The emphasis of the review is on the structure of RetGC and guanylyl cyclase activating proteins (GCAPs) in relation to their functional role in photoreceptors and congenital diseases of photoreceptors. In addition to that, the structure and function of retinal degeneration-3 protein (RD3), which regulates RetGC in a calcium-independent manner, is discussed in detail in connections with its role in photoreceptor biology and inherited retinal blindness.
format Online
Article
Text
id pubmed-8329130
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-83291302021-08-31 Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein Dizhoor, Alexander M. Peshenko, Igor V. Pflugers Arch Invited Review This article presents a brief overview of the main biochemical and cellular processes involved in regulation of cyclic GMP production in photoreceptors. The main focus is on how the fluctuations of free calcium concentrations in photoreceptors between light and dark regulate the activity of retinal membrane guanylyl cyclase (RetGC) via calcium sensor proteins. The emphasis of the review is on the structure of RetGC and guanylyl cyclase activating proteins (GCAPs) in relation to their functional role in photoreceptors and congenital diseases of photoreceptors. In addition to that, the structure and function of retinal degeneration-3 protein (RD3), which regulates RetGC in a calcium-independent manner, is discussed in detail in connections with its role in photoreceptor biology and inherited retinal blindness. Springer Berlin Heidelberg 2021-02-03 2021 /pmc/articles/PMC8329130/ /pubmed/33537894 http://dx.doi.org/10.1007/s00424-021-02523-4 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Invited Review
Dizhoor, Alexander M.
Peshenko, Igor V.
Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
title Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
title_full Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
title_fullStr Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
title_full_unstemmed Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
title_short Regulation of retinal membrane guanylyl cyclase (RetGC) by negative calcium feedback and RD3 protein
title_sort regulation of retinal membrane guanylyl cyclase (retgc) by negative calcium feedback and rd3 protein
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329130/
https://www.ncbi.nlm.nih.gov/pubmed/33537894
http://dx.doi.org/10.1007/s00424-021-02523-4
work_keys_str_mv AT dizhooralexanderm regulationofretinalmembraneguanylylcyclaseretgcbynegativecalciumfeedbackandrd3protein
AT peshenkoigorv regulationofretinalmembraneguanylylcyclaseretgcbynegativecalciumfeedbackandrd3protein

Ejemplares similares