Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy

Fatty acid synthase (FASN) is the only human lipogenic enzyme available for de novo fatty acid synthesis and is often highly expressed in cancer cells. We found that FASN mRNA levels were significantly higher in acute myeloid leukemia (AML) patients than in healthy granulocytes or CD34(+) hematopoie...

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Detalles Bibliográficos
Autores principales: Humbert, Magali, Seiler, Kristina, Mosimann, Severin, Rentsch, Vreni, Sharma, Katyayani, Pandey, Amit V., McKenna, Sharon L., Tschan, Mario P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329134/
https://www.ncbi.nlm.nih.gov/pubmed/33742137
http://dx.doi.org/10.1038/s41418-021-00768-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329134/
https://www.ncbi.nlm.nih.gov/pubmed/33742137
http://dx.doi.org/10.1038/s41418-021-00768-1

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