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Emerging liver organoid platforms and technologies
Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role in regulating body homeostasis as well as drug meta...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329140/ https://www.ncbi.nlm.nih.gov/pubmed/34341842 http://dx.doi.org/10.1186/s13619-021-00089-1 |
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author | Lam, Do Thuy Uyen Ha Dan, Yock Young Chan, Yun-Shen Ng, Huck-Hui |
author_facet | Lam, Do Thuy Uyen Ha Dan, Yock Young Chan, Yun-Shen Ng, Huck-Hui |
author_sort | Lam, Do Thuy Uyen Ha |
collection | PubMed |
description | Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role in regulating body homeostasis as well as drug metabolism. An accurate liver replica should contain the multiple cell types found in the organ and these cells should be spatially organized to resemble tissue structures. More importantly, the in vitro model should recapitulate cellular and tissue level functions. Progress in cell culture techniques and bioengineering approaches have greatly accelerated the development of advance 3-dimensional (3D) cellular models commonly referred to as liver organoids. These 3D models described range from single to multiple cell type containing cultures with diverse applications from establishing patient-specific liver cells to modeling of chronic liver diseases and regenerative therapy. Each organoid platform is advantageous for specific applications and presents its own limitations. This review aims to provide a comprehensive summary of major liver organoid platforms and technologies developed for diverse applications. |
format | Online Article Text |
id | pubmed-8329140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-83291402021-08-19 Emerging liver organoid platforms and technologies Lam, Do Thuy Uyen Ha Dan, Yock Young Chan, Yun-Shen Ng, Huck-Hui Cell Regen Review Building human organs in a dish has been a long term goal of researchers in pursue of physiologically relevant models of human disease and for replacement of worn out and diseased organs. The liver has been an organ of interest for its central role in regulating body homeostasis as well as drug metabolism. An accurate liver replica should contain the multiple cell types found in the organ and these cells should be spatially organized to resemble tissue structures. More importantly, the in vitro model should recapitulate cellular and tissue level functions. Progress in cell culture techniques and bioengineering approaches have greatly accelerated the development of advance 3-dimensional (3D) cellular models commonly referred to as liver organoids. These 3D models described range from single to multiple cell type containing cultures with diverse applications from establishing patient-specific liver cells to modeling of chronic liver diseases and regenerative therapy. Each organoid platform is advantageous for specific applications and presents its own limitations. This review aims to provide a comprehensive summary of major liver organoid platforms and technologies developed for diverse applications. Springer Singapore 2021-08-03 /pmc/articles/PMC8329140/ /pubmed/34341842 http://dx.doi.org/10.1186/s13619-021-00089-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Lam, Do Thuy Uyen Ha Dan, Yock Young Chan, Yun-Shen Ng, Huck-Hui Emerging liver organoid platforms and technologies |
title | Emerging liver organoid platforms and technologies |
title_full | Emerging liver organoid platforms and technologies |
title_fullStr | Emerging liver organoid platforms and technologies |
title_full_unstemmed | Emerging liver organoid platforms and technologies |
title_short | Emerging liver organoid platforms and technologies |
title_sort | emerging liver organoid platforms and technologies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329140/ https://www.ncbi.nlm.nih.gov/pubmed/34341842 http://dx.doi.org/10.1186/s13619-021-00089-1 |
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