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Characterization of the structural forces governing the reversibility of the thermal unfolding of the human acidic fibroblast growth factor

Human acidic fibroblast growth factor (hFGF1) is an all beta-sheet protein that is involved in the regulation of key cellular processes including cell proliferation and wound healing. hFGF1 is known to aggregate when subjected to thermal unfolding. In this study, we investigate the equilibrium unfol...

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Detalles Bibliográficos
Autores principales: Agrawal, Shilpi, Govind Kumar, Vivek, Gundampati, Ravi Kumar, Moradi, Mahmoud, Kumar, Thallapuranam Krishnaswamy Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329156/
https://www.ncbi.nlm.nih.gov/pubmed/34341408
http://dx.doi.org/10.1038/s41598-021-95050-2