Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months

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The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behav...

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Detalles Bibliográficos
Autores principales: Provenzi, Livio, Mambretti, Fabiana, Villa, Marco, Grumi, Serena, Citterio, Andrea, Bertazzoli, Emanuela, Biasucci, Giacomo, Decembrino, Lidia, Falcone, Rossana, Gardella, Barbara, Longo, Maria Roberta, Nacinovich, Renata, Pisoni, Camilla, Prefumo, Federico, Orcesi, Simona, Scelsa, Barbara, Giorda, Roberto, Borgatti, Renato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329206/
https://www.ncbi.nlm.nih.gov/pubmed/34341434
http://dx.doi.org/10.1038/s41598-021-95053-z
Descripción
Sumario:The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.

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