Cargando…
Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months
The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behav...
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329206/ https://www.ncbi.nlm.nih.gov/pubmed/34341434 http://dx.doi.org/10.1038/s41598-021-95053-z |
| _version_ | 1783732449287602176 |
|---|---|
| author | Provenzi, Livio Mambretti, Fabiana Villa, Marco Grumi, Serena Citterio, Andrea Bertazzoli, Emanuela Biasucci, Giacomo Decembrino, Lidia Falcone, Rossana Gardella, Barbara Longo, Maria Roberta Nacinovich, Renata Pisoni, Camilla Prefumo, Federico Orcesi, Simona Scelsa, Barbara Giorda, Roberto Borgatti, Renato |
| author_facet | Provenzi, Livio Mambretti, Fabiana Villa, Marco Grumi, Serena Citterio, Andrea Bertazzoli, Emanuela Biasucci, Giacomo Decembrino, Lidia Falcone, Rossana Gardella, Barbara Longo, Maria Roberta Nacinovich, Renata Pisoni, Camilla Prefumo, Federico Orcesi, Simona Scelsa, Barbara Giorda, Roberto Borgatti, Renato |
| author_sort | Provenzi, Livio |
| collection | PubMed |
| description | The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months. |
| format | Online Article Text |
| id | pubmed-8329206 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83292062021-08-04 Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months Provenzi, Livio Mambretti, Fabiana Villa, Marco Grumi, Serena Citterio, Andrea Bertazzoli, Emanuela Biasucci, Giacomo Decembrino, Lidia Falcone, Rossana Gardella, Barbara Longo, Maria Roberta Nacinovich, Renata Pisoni, Camilla Prefumo, Federico Orcesi, Simona Scelsa, Barbara Giorda, Roberto Borgatti, Renato Sci Rep Article The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months. Nature Publishing Group UK 2021-08-02 /pmc/articles/PMC8329206/ /pubmed/34341434 http://dx.doi.org/10.1038/s41598-021-95053-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Provenzi, Livio Mambretti, Fabiana Villa, Marco Grumi, Serena Citterio, Andrea Bertazzoli, Emanuela Biasucci, Giacomo Decembrino, Lidia Falcone, Rossana Gardella, Barbara Longo, Maria Roberta Nacinovich, Renata Pisoni, Camilla Prefumo, Federico Orcesi, Simona Scelsa, Barbara Giorda, Roberto Borgatti, Renato Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months |
| title | Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months |
| title_full | Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months |
| title_fullStr | Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months |
| title_full_unstemmed | Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months |
| title_short | Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months |
| title_sort | hidden pandemic: covid-19-related stress, slc6a4 methylation, and infants’ temperament at 3 months |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329206/ https://www.ncbi.nlm.nih.gov/pubmed/34341434 http://dx.doi.org/10.1038/s41598-021-95053-z |
| work_keys_str_mv | AT provenzilivio hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT mambrettifabiana hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT villamarco hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT grumiserena hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT citterioandrea hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT bertazzoliemanuela hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT biasuccigiacomo hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT decembrinolidia hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT falconerossana hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT gardellabarbara hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT longomariaroberta hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT nacinovichrenata hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT pisonicamilla hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT prefumofederico hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT orcesisimona hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT scelsabarbara hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT giordaroberto hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months AT borgattirenato hiddenpandemiccovid19relatedstressslc6a4methylationandinfantstemperamentat3months |