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Optimal solution of the fractional order breast cancer competition model

In this article, a fractional order breast cancer competition model (F-BCCM) under the Caputo fractional derivative is analyzed. A new set of basis functions, namely the generalized shifted Legendre polynomials, is proposed to deal with the solutions of F-BCCM. The F-BCCM describes the dynamics invo...

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Autores principales: Hassani, H., Machado, J. A. Tenreiro, Avazzadeh, Z., Safari, E., Mehrabi, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329307/
https://www.ncbi.nlm.nih.gov/pubmed/34341390
http://dx.doi.org/10.1038/s41598-021-94875-1
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author Hassani, H.
Machado, J. A. Tenreiro
Avazzadeh, Z.
Safari, E.
Mehrabi, S.
author_facet Hassani, H.
Machado, J. A. Tenreiro
Avazzadeh, Z.
Safari, E.
Mehrabi, S.
author_sort Hassani, H.
collection PubMed
description In this article, a fractional order breast cancer competition model (F-BCCM) under the Caputo fractional derivative is analyzed. A new set of basis functions, namely the generalized shifted Legendre polynomials, is proposed to deal with the solutions of F-BCCM. The F-BCCM describes the dynamics involving a variety of cancer factors, such as the stem, tumor and healthy cells, as well as the effects of excess estrogen and the body’s natural immune response on the cell populations. After combining the operational matrices with the Lagrange multipliers technique we obtain an optimization method for solving the F-BCCM whose convergence is investigated. Several examples show that a few number of basis functions lead to the satisfactory results. In fact, numerical experiments not only confirm the accuracy but also the practicability and computational efficiency of the devised technique.
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spelling pubmed-83293072021-08-04 Optimal solution of the fractional order breast cancer competition model Hassani, H. Machado, J. A. Tenreiro Avazzadeh, Z. Safari, E. Mehrabi, S. Sci Rep Article In this article, a fractional order breast cancer competition model (F-BCCM) under the Caputo fractional derivative is analyzed. A new set of basis functions, namely the generalized shifted Legendre polynomials, is proposed to deal with the solutions of F-BCCM. The F-BCCM describes the dynamics involving a variety of cancer factors, such as the stem, tumor and healthy cells, as well as the effects of excess estrogen and the body’s natural immune response on the cell populations. After combining the operational matrices with the Lagrange multipliers technique we obtain an optimization method for solving the F-BCCM whose convergence is investigated. Several examples show that a few number of basis functions lead to the satisfactory results. In fact, numerical experiments not only confirm the accuracy but also the practicability and computational efficiency of the devised technique. Nature Publishing Group UK 2021-08-02 /pmc/articles/PMC8329307/ /pubmed/34341390 http://dx.doi.org/10.1038/s41598-021-94875-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hassani, H.
Machado, J. A. Tenreiro
Avazzadeh, Z.
Safari, E.
Mehrabi, S.
Optimal solution of the fractional order breast cancer competition model
title Optimal solution of the fractional order breast cancer competition model
title_full Optimal solution of the fractional order breast cancer competition model
title_fullStr Optimal solution of the fractional order breast cancer competition model
title_full_unstemmed Optimal solution of the fractional order breast cancer competition model
title_short Optimal solution of the fractional order breast cancer competition model
title_sort optimal solution of the fractional order breast cancer competition model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329307/
https://www.ncbi.nlm.nih.gov/pubmed/34341390
http://dx.doi.org/10.1038/s41598-021-94875-1
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