Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female

Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophil...

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Detalles Bibliográficos
Autores principales: Ramachandran, Prasanna Venkatesh, Healy, C. Mary, Lambert, Elton M., Guerra, Deyanara, Curry, Choladda V., Vogel, Tiphanie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329340/
https://www.ncbi.nlm.nih.gov/pubmed/34354968
http://dx.doi.org/10.3389/fped.2021.674317
Descripción
Sumario:Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophilia and highly elevated IgE levels. Laboratory and histopathologic evaluation revealed an unlikely diagnosis of Kimura Disease. We discuss the differential diagnosis of a neck mass with prominent eosinophils on histology, and review support for T-helper type 2 (Th2) cell activation and hyper-IgE in Kimura Disease.

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