Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female

Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophil...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramachandran, Prasanna Venkatesh, Healy, C. Mary, Lambert, Elton M., Guerra, Deyanara, Curry, Choladda V., Vogel, Tiphanie P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329340/
https://www.ncbi.nlm.nih.gov/pubmed/34354968
http://dx.doi.org/10.3389/fped.2021.674317
_version_ 1783732478936088576
author Ramachandran, Prasanna Venkatesh
Healy, C. Mary
Lambert, Elton M.
Guerra, Deyanara
Curry, Choladda V.
Vogel, Tiphanie P.
author_facet Ramachandran, Prasanna Venkatesh
Healy, C. Mary
Lambert, Elton M.
Guerra, Deyanara
Curry, Choladda V.
Vogel, Tiphanie P.
author_sort Ramachandran, Prasanna Venkatesh
collection PubMed
description Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophilia and highly elevated IgE levels. Laboratory and histopathologic evaluation revealed an unlikely diagnosis of Kimura Disease. We discuss the differential diagnosis of a neck mass with prominent eosinophils on histology, and review support for T-helper type 2 (Th2) cell activation and hyper-IgE in Kimura Disease.
format Online
Article
Text
id pubmed-8329340
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-83293402021-08-04 Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female Ramachandran, Prasanna Venkatesh Healy, C. Mary Lambert, Elton M. Guerra, Deyanara Curry, Choladda V. Vogel, Tiphanie P. Front Pediatr Pediatrics Elevated immunoglobulin E (IgE) levels can be associated with infectious, allergic and inflammatory disorders, and rarely as a manifestation of an inborn error of immunity. Here we report the case of an adolescent female who presented with a gradually enlarging neck mass, lymphadenopathy, eosinophilia and highly elevated IgE levels. Laboratory and histopathologic evaluation revealed an unlikely diagnosis of Kimura Disease. We discuss the differential diagnosis of a neck mass with prominent eosinophils on histology, and review support for T-helper type 2 (Th2) cell activation and hyper-IgE in Kimura Disease. Frontiers Media S.A. 2021-07-20 /pmc/articles/PMC8329340/ /pubmed/34354968 http://dx.doi.org/10.3389/fped.2021.674317 Text en Copyright © 2021 Ramachandran, Healy, Lambert, Guerra, Curry and Vogel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Ramachandran, Prasanna Venkatesh
Healy, C. Mary
Lambert, Elton M.
Guerra, Deyanara
Curry, Choladda V.
Vogel, Tiphanie P.
Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female
title Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female
title_full Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female
title_fullStr Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female
title_full_unstemmed Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female
title_short Case Report: Hyper IgE, but Not the Usual Suspects–Kimura Disease in an Adolescent Female
title_sort case report: hyper ige, but not the usual suspects–kimura disease in an adolescent female
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329340/
https://www.ncbi.nlm.nih.gov/pubmed/34354968
http://dx.doi.org/10.3389/fped.2021.674317
work_keys_str_mv AT ramachandranprasannavenkatesh casereporthyperigebutnottheusualsuspectskimuradiseaseinanadolescentfemale
AT healycmary casereporthyperigebutnottheusualsuspectskimuradiseaseinanadolescentfemale
AT lamberteltonm casereporthyperigebutnottheusualsuspectskimuradiseaseinanadolescentfemale
AT guerradeyanara casereporthyperigebutnottheusualsuspectskimuradiseaseinanadolescentfemale
AT currycholaddav casereporthyperigebutnottheusualsuspectskimuradiseaseinanadolescentfemale
AT vogeltiphaniep casereporthyperigebutnottheusualsuspectskimuradiseaseinanadolescentfemale

Ejemplares similares