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The Vital Roles of LINC00662 in Human Cancers

Long non-coding RNAs (lncRNAs) play crucial roles in many human diseases, particularly in tumorigenicity and progression. Although lncRNA research studies are increasing rapidly, our understanding of lncRNA mechanisms is still incomplete. The long intergenic non-protein coding RNA 662 (LINC00662) is...

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Autores principales: He, Yuting, Xu, Yating, Yu, Xiao, Sun, Zongzong, Guo, Wenzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329443/
https://www.ncbi.nlm.nih.gov/pubmed/34354995
http://dx.doi.org/10.3389/fcell.2021.711352
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author He, Yuting
Xu, Yating
Yu, Xiao
Sun, Zongzong
Guo, Wenzhi
author_facet He, Yuting
Xu, Yating
Yu, Xiao
Sun, Zongzong
Guo, Wenzhi
author_sort He, Yuting
collection PubMed
description Long non-coding RNAs (lncRNAs) play crucial roles in many human diseases, particularly in tumorigenicity and progression. Although lncRNA research studies are increasing rapidly, our understanding of lncRNA mechanisms is still incomplete. The long intergenic non-protein coding RNA 662 (LINC00662) is a novel lncRNA, and accumulating evidence suggests that it is related to a variety of tumors in multiple systems, including the respiratory, reproductive, nervous, and digestive systems. LINC00662 has been shown to be upregulated in malignant tumors and has been confirmed to promote the development of malignant tumors. LINC00662 has also been reported to facilitate a variety of cellular events, such as tumor-cell proliferation, invasion, and migration, and its expression has been correlated to clinicopathological characteristics in patients with tumors. In terms of mechanisms, LINC00662 regulates gene expression by interacting with both proteins and with RNAs, so it may be a potential biomarker for cancer diagnosis, prognosis, and treatment. This article reviews the expression patterns, biological functions, and underlying molecular mechanisms of LINC00662 in tumors.
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spelling pubmed-83294432021-08-04 The Vital Roles of LINC00662 in Human Cancers He, Yuting Xu, Yating Yu, Xiao Sun, Zongzong Guo, Wenzhi Front Cell Dev Biol Cell and Developmental Biology Long non-coding RNAs (lncRNAs) play crucial roles in many human diseases, particularly in tumorigenicity and progression. Although lncRNA research studies are increasing rapidly, our understanding of lncRNA mechanisms is still incomplete. The long intergenic non-protein coding RNA 662 (LINC00662) is a novel lncRNA, and accumulating evidence suggests that it is related to a variety of tumors in multiple systems, including the respiratory, reproductive, nervous, and digestive systems. LINC00662 has been shown to be upregulated in malignant tumors and has been confirmed to promote the development of malignant tumors. LINC00662 has also been reported to facilitate a variety of cellular events, such as tumor-cell proliferation, invasion, and migration, and its expression has been correlated to clinicopathological characteristics in patients with tumors. In terms of mechanisms, LINC00662 regulates gene expression by interacting with both proteins and with RNAs, so it may be a potential biomarker for cancer diagnosis, prognosis, and treatment. This article reviews the expression patterns, biological functions, and underlying molecular mechanisms of LINC00662 in tumors. Frontiers Media S.A. 2021-07-20 /pmc/articles/PMC8329443/ /pubmed/34354995 http://dx.doi.org/10.3389/fcell.2021.711352 Text en Copyright © 2021 He, Xu, Yu, Sun and Guo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
He, Yuting
Xu, Yating
Yu, Xiao
Sun, Zongzong
Guo, Wenzhi
The Vital Roles of LINC00662 in Human Cancers
title The Vital Roles of LINC00662 in Human Cancers
title_full The Vital Roles of LINC00662 in Human Cancers
title_fullStr The Vital Roles of LINC00662 in Human Cancers
title_full_unstemmed The Vital Roles of LINC00662 in Human Cancers
title_short The Vital Roles of LINC00662 in Human Cancers
title_sort vital roles of linc00662 in human cancers
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329443/
https://www.ncbi.nlm.nih.gov/pubmed/34354995
http://dx.doi.org/10.3389/fcell.2021.711352
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