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A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model

Wounds may remain open for a few weeks in severe burns, which provide an entry point for pathogens and microorganisms invading. Thus, wound dressings with long-term antimicrobial activity are crucial for severe burn wound healing. Here, a sandwich structure composite wound dressing anchored with sil...

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Autores principales: Yang, Jianmin, Huang, Yufeng, Dai, Jiajia, Shi, Xianai, Zheng, Yunquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329475/
https://www.ncbi.nlm.nih.gov/pubmed/34350029
http://dx.doi.org/10.1093/rb/rbab037
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author Yang, Jianmin
Huang, Yufeng
Dai, Jiajia
Shi, Xianai
Zheng, Yunquan
author_facet Yang, Jianmin
Huang, Yufeng
Dai, Jiajia
Shi, Xianai
Zheng, Yunquan
author_sort Yang, Jianmin
collection PubMed
description Wounds may remain open for a few weeks in severe burns, which provide an entry point for pathogens and microorganisms invading. Thus, wound dressings with long-term antimicrobial activity are crucial for severe burn wound healing. Here, a sandwich structure composite wound dressing anchored with silver nanoparticles (AgNPs) was developed for severe burn wound healing. AgNPs were in situ synthesized on the fibers of chitosan nonwoven fabric (CSNWF) as the interlayer of wound dressing for sustained release of silver ion. The firmly anchored AgNPs could prevent its entry into the body, thereby eliminating the toxicity of nanomaterials. The outer layer was a polyurethane membrane, which has a nanoporous structure that could maintain free transmission of water vapor. Chitosan/collagen sponge was selected as the inner layer because of its excellent biocompatibility and biodegradability. The presence of AgNPs in the CSNWF was fully characterized, and the high antibacterial activity of CSNWF/AgNPs was confirmed by against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The superior wound healing effect on deep dermal burns of presented composite wound dressing was demonstrated in a porcine model. Our finding suggested that the prepared AgNPs doped sandwich structure composite wound dressing has great potential application in severe wound care.
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spelling pubmed-83294752021-08-03 A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model Yang, Jianmin Huang, Yufeng Dai, Jiajia Shi, Xianai Zheng, Yunquan Regen Biomater Research Article Wounds may remain open for a few weeks in severe burns, which provide an entry point for pathogens and microorganisms invading. Thus, wound dressings with long-term antimicrobial activity are crucial for severe burn wound healing. Here, a sandwich structure composite wound dressing anchored with silver nanoparticles (AgNPs) was developed for severe burn wound healing. AgNPs were in situ synthesized on the fibers of chitosan nonwoven fabric (CSNWF) as the interlayer of wound dressing for sustained release of silver ion. The firmly anchored AgNPs could prevent its entry into the body, thereby eliminating the toxicity of nanomaterials. The outer layer was a polyurethane membrane, which has a nanoporous structure that could maintain free transmission of water vapor. Chitosan/collagen sponge was selected as the inner layer because of its excellent biocompatibility and biodegradability. The presence of AgNPs in the CSNWF was fully characterized, and the high antibacterial activity of CSNWF/AgNPs was confirmed by against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The superior wound healing effect on deep dermal burns of presented composite wound dressing was demonstrated in a porcine model. Our finding suggested that the prepared AgNPs doped sandwich structure composite wound dressing has great potential application in severe wound care. Oxford University Press 2021-08-03 /pmc/articles/PMC8329475/ /pubmed/34350029 http://dx.doi.org/10.1093/rb/rbab037 Text en © The Author(s) 2021. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Jianmin
Huang, Yufeng
Dai, Jiajia
Shi, Xianai
Zheng, Yunquan
A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
title A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
title_full A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
title_fullStr A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
title_full_unstemmed A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
title_short A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
title_sort sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329475/
https://www.ncbi.nlm.nih.gov/pubmed/34350029
http://dx.doi.org/10.1093/rb/rbab037
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