Discovery of pentapeptide-inhibitor hits targeting FKBP51 by combining computational modeling and X-ray crystallography

FKBP51 is well-known as a cochaperone of Hsp90 machinery and implicated in many human diseases including stress-related diseases, tau-mediated neurodegeneration and cancers, which makes FKBP51 an attractive drug target for the therapy of FKBP51-associated diseases. However, it has been reported that...

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Detalles Bibliográficos
Autores principales: Han, Jian-Ting, Zhu, Yongchang, Pan, Da-Bo, Xue, Hong-Xiang, Wang, Shuang, Peng, Yali, Liu, Huanxiang, He, Yong-Xing, Yao, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329522/
https://www.ncbi.nlm.nih.gov/pubmed/34401048
http://dx.doi.org/10.1016/j.csbj.2021.07.015

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