Large Intronic Deletion of the Fragile Site Gene PRKN Dramatically Lowers Its Fragility Without Impacting Gene Expression

Common chromosomal fragile sites (CFSs) are genomic regions prone to form breaks and gaps on metaphase chromosomes during conditions of replication stress. Moreover, CFSs are hotspots for deletions and amplifications in cancer genomes. Fragility at CFSs is caused by transcription of extremely large...

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Detalles Bibliográficos
Autores principales: Munk, Sebastian H. N., Voutsinos, Vasileios, Oestergaard, Vibe H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329550/
https://www.ncbi.nlm.nih.gov/pubmed/34354738
http://dx.doi.org/10.3389/fgene.2021.695172

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329550/
https://www.ncbi.nlm.nih.gov/pubmed/34354738
http://dx.doi.org/10.3389/fgene.2021.695172

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