Cargando…

Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer?

Pancreatic cancer is an aggressive, devastating disease due to its invasiveness, rapid progression, and resistance to surgical, pharmacological, chemotherapy, and radiotherapy treatments. The disease develops from PanINs lesions that progress through different stages. KRAS mutations are frequently o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferreira, Roseane Guimarães, Narvaez, Luis Eduardo Mosquera, Espíndola, Kaio Murilo Monteiro, Rosario, Amanda Caroline R. S., Lima, Wenddy Graziela N., Monteiro, Marta Chagas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329661/ https://www.ncbi.nlm.nih.gov/pubmed/34354940 http://dx.doi.org/10.3389/fonc.2021.594917

Ejemplares similares

Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma
por: Espíndola, Kaio Murilo Monteiro, et al.
Publicado: (2019)

Effects of nimesulide on kainate-induced in vitro oxidative damage in rat brain homogenates
por: Candelario-Jalil, Eduardo, et al.
Publicado: (2003)

Survey on appropriateness of use of nimesulide in nine European countries
por: Franchi, Silvia, et al.
Publicado: (2015)

Nimesulide increases the aldehyde oxidase activity of humans and rats
por: Zhou, Lei, et al.
Publicado: (2020)

Comparison of analgesic effects of nimesulide, paracetamol, and their combination in animal models
por: Ahmed, Mushtaq, et al.
Publicado: (2010)

Nimesulide induced leukocytoclastic vasculitis and hepatitis: a case report
por: Bhattacharya, Prasanta Kumar, et al.
Publicado: (2015)

Effects of nimesulide on the small intestine mucositis induced by methotrexate in rats
por: Arslan, Aynur, et al.
Publicado: (2016)

Development of in vitro - in vivo correlations for newly optimized Nimesulide formulations
por: Hanif, Muhammad, et al.
Publicado: (2018)

Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis
por: Kwon, Jeongyoon, et al.
Publicado: (2019)

Impact of combined treatment with nimesulide and cisplatin on oral carcinoma cells
por: Barac, Aleksandra, et al.
Publicado: (2017)

Kounis syndrome secondary to nimesulide ingestion: a case report
por: Shrimanth, Yamasandi Siddegowda, et al.
Publicado: (2021)

Lallemantia reylenne seeds as superdisintegrant: Formulation and evaluation of nimesulide orodispersible tablets
por: Malik, Karan, et al.
Publicado: (2011)

Fixed drug eruption to nimesulide: an exuberant presentation confirmed by patch testing
por: Marques, Lidiane Pereira, et al.
Publicado: (2018)

Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action
por: Trindade, Joana D’Arc S., et al.
Publicado: (2021)

Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering †
por: Vunnam, Nagamani, et al.
Publicado: (2023)

Nimesulide inhibited the growth of hypopharyngeal carcinoma cells via suppressing Survivin expression
por: Jia-Jun, Tian, et al.
Publicado: (2012)

Bilateral spontaneous retroperitoneal bleeding in a patient on nimesulide: a case report
por: Mitsogiannis, Iraklis C, et al.
Publicado: (2011)

Study of Nimesulide Release from Solid Pharmaceutical Formulations in Tween 80 Solutions
por: Purcaru, Stefana-Oana, et al.
Publicado: (2010)

Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4
por: Yang, Shaoqi, et al.
Publicado: (2012)

Nimesulide Improves the Symptomatic and Disease Modifying Effects of Leflunomide in Collagen Induced Arthritis
por: Al-Abd, Ahmed M., et al.
Publicado: (2014)

Thermal Behavior of the Nimesulide-Salicylic Acid Eutectic Mixtures Prepared by Mechanosynthesis and Recrystallization
por: Georgescu, Mona, et al.
Publicado: (2021)

Crystallization of Amorphous Nimesulide: The Relationship between Crystal Growth Kinetics and Liquid Dynamics
por: Shi, Qin, et al.
Publicado: (2023)

The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer
por: Eklöf, V, et al.
Publicado: (2013)

Liposomal Aloe vera trans-emulgel drug delivery of naproxen and nimesulide: A study
por: Venkataharsha, Panuganti, et al.
Publicado: (2015)

Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide
por: Luo, Wen, et al.
Publicado: (2020)

A survey and optical microscopy in pilot comparative analysis of generic and original nimesulide granules
por: Leonenko, Pavlo, et al.
Publicado: (2021)

Methoxybenzamide derivative of nimesulide from anti-fever to anti-cancer: Chemical characterization and cytotoxicity
por: Jaragh-Alhadad, Laila A., et al.
Publicado: (2022)

Molecular Characterization of a First-in-Human Clinical Response to Nimesulide in Acute Myeloid Leukemia
por: Tomaz, Victória, et al.
Publicado: (2022)

A Review of Potential Use of Amazonian Oils in the Synthesis of Organogels for Cosmetic Application
por: Mosquera Narvaez, Luis Eduardo, et al.
Publicado: (2022)

Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat
por: Candelario-Jalil, Eduardo, et al.
Publicado: (2005)

Alpha-Lipoic Acid and Its Enantiomers Prevent Methemoglobin Formation and DNA Damage Induced by Dapsone Hydroxylamine: Molecular Mechanism and Antioxidant Action
por: Espíndola, Kaio Murilo Monteiro, et al.
Publicado: (2022)

Targeting KRAS in Pancreatic Cancer
por: Cowzer, Darren, et al.
Publicado: (2022)

Nimesulide inhibits protein kinase C epsilon and substance P in sensory neurons – comparison with paracetamol
por: Vellani, Vittorio, et al.
Publicado: (2011)

Enhancement of Antinociception by Co-administrations of Nefopam, Morphine, and Nimesulide in a Rat Model of Neuropathic Pain
por: Saghaei, Elham, et al.
Publicado: (2012)

Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva(®)), nimesulide, and acetaminophen
por: Francesco, Di Pierro, et al.
Publicado: (2013)

Effects of Subchronic Treatment with Ibuprofen and Nimesulide on Spatial Memory and NMDAR Subunits Expression in Aged Rats
por: Ozturk Bilgin, Ozlem, et al.
Publicado: (2013)

Suppression of Intestinal Polyp Development by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, in Min Mice
por: Nakatsugi, Seiichi, et al.
Publicado: (1997)

Effects of PTEN Loss and Activated KRAS Overexpression on Mechanical Properties of Breast Epithelial Cells
por: Linthicum, Will, et al.
Publicado: (2018)

Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome
por: Lemstrova, Radmila, et al.
Publicado: (2017)

Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma
por: Candido, Tuany Zambroti, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ji1g40beeovohm164u98do18es