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Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study

The right parietal lobe plays an important role in body image, and disorders of body image emerge after lesions in the parietal lobe or with parietal lobe epilepsy. Body image disorder also often accompanies upper-limb amputation, in which the patient misperceives that their missing limb is still pa...

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Autores principales: Bao, Bingbo, Wei, Haifeng, Luo, Pengbo, Zhu, Hongyi, Hu, Wencheng, Sun, Yi, Shen, Junjie, Zhu, Tianhao, Lin, Junqing, Huang, Tengli, Li, Jing, Wang, Zhibin, Li, Yuehua, Zheng, Xianyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329664/
https://www.ncbi.nlm.nih.gov/pubmed/34354568
http://dx.doi.org/10.3389/fnins.2021.704079
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author Bao, Bingbo
Wei, Haifeng
Luo, Pengbo
Zhu, Hongyi
Hu, Wencheng
Sun, Yi
Shen, Junjie
Zhu, Tianhao
Lin, Junqing
Huang, Tengli
Li, Jing
Wang, Zhibin
Li, Yuehua
Zheng, Xianyou
author_facet Bao, Bingbo
Wei, Haifeng
Luo, Pengbo
Zhu, Hongyi
Hu, Wencheng
Sun, Yi
Shen, Junjie
Zhu, Tianhao
Lin, Junqing
Huang, Tengli
Li, Jing
Wang, Zhibin
Li, Yuehua
Zheng, Xianyou
author_sort Bao, Bingbo
collection PubMed
description The right parietal lobe plays an important role in body image, and disorders of body image emerge after lesions in the parietal lobe or with parietal lobe epilepsy. Body image disorder also often accompanies upper-limb amputation, in which the patient misperceives that their missing limb is still part of their body. Cortical reorganization is known to occur after upper-limb amputation, but it is not clear how widespread and to what degree functional connectivity (FC) is reorganized post-amputation, nor whether such changes might be related to misperceptions of body image. Twenty-four subjects who had a traumatically upper-limb amputees (ULAs) and 24 age-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. Regions of interest (ROIs) in the right superior parietal gyrus (SPG_R) and right inferior parietal lobule (IPL_R) were defined using BrainNet Viewer. We calculated the amplitude of low-frequency fluctuations (ALFF) in ROIs and correlated the ROI mean amplitude of low-frequency fluctuations (mALFF) and mean scores on the phantom limb sensation (PLS) scale and beck depression index (BDI). We also calculated ROIs and whole-brain FC. Compared to the HC group, we observed significantly increased activation (mALFF) in ROIs of the ULA group. Moreover, correlation analyses revealed a significant positive correlation between ROI mALFF and scores on the PLS. There was a significant negative correlation between the SPG_R mALFF and BDI scores. Seed-based, whole-brain FC analysis revealed that FC in the ULA group significantly decreased in many brain regions across the entire brain. The right parietal lobe appears to be involved in some aspect of body awareness and depression in amputation patients. Upper-limb amputation results not only in reorganization in the local brain area formerly representing the missing limb, but also results in more widespread reorganization through FC changes in whole brain.
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spelling pubmed-83296642021-08-04 Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study Bao, Bingbo Wei, Haifeng Luo, Pengbo Zhu, Hongyi Hu, Wencheng Sun, Yi Shen, Junjie Zhu, Tianhao Lin, Junqing Huang, Tengli Li, Jing Wang, Zhibin Li, Yuehua Zheng, Xianyou Front Neurosci Neuroscience The right parietal lobe plays an important role in body image, and disorders of body image emerge after lesions in the parietal lobe or with parietal lobe epilepsy. Body image disorder also often accompanies upper-limb amputation, in which the patient misperceives that their missing limb is still part of their body. Cortical reorganization is known to occur after upper-limb amputation, but it is not clear how widespread and to what degree functional connectivity (FC) is reorganized post-amputation, nor whether such changes might be related to misperceptions of body image. Twenty-four subjects who had a traumatically upper-limb amputees (ULAs) and 24 age-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. Regions of interest (ROIs) in the right superior parietal gyrus (SPG_R) and right inferior parietal lobule (IPL_R) were defined using BrainNet Viewer. We calculated the amplitude of low-frequency fluctuations (ALFF) in ROIs and correlated the ROI mean amplitude of low-frequency fluctuations (mALFF) and mean scores on the phantom limb sensation (PLS) scale and beck depression index (BDI). We also calculated ROIs and whole-brain FC. Compared to the HC group, we observed significantly increased activation (mALFF) in ROIs of the ULA group. Moreover, correlation analyses revealed a significant positive correlation between ROI mALFF and scores on the PLS. There was a significant negative correlation between the SPG_R mALFF and BDI scores. Seed-based, whole-brain FC analysis revealed that FC in the ULA group significantly decreased in many brain regions across the entire brain. The right parietal lobe appears to be involved in some aspect of body awareness and depression in amputation patients. Upper-limb amputation results not only in reorganization in the local brain area formerly representing the missing limb, but also results in more widespread reorganization through FC changes in whole brain. Frontiers Media S.A. 2021-07-20 /pmc/articles/PMC8329664/ /pubmed/34354568 http://dx.doi.org/10.3389/fnins.2021.704079 Text en Copyright © 2021 Bao, Wei, Luo, Zhu, Hu, Sun, Shen, Zhu, Lin, Huang, Li, Wang, Li and Zheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bao, Bingbo
Wei, Haifeng
Luo, Pengbo
Zhu, Hongyi
Hu, Wencheng
Sun, Yi
Shen, Junjie
Zhu, Tianhao
Lin, Junqing
Huang, Tengli
Li, Jing
Wang, Zhibin
Li, Yuehua
Zheng, Xianyou
Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study
title Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study
title_full Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study
title_fullStr Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study
title_full_unstemmed Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study
title_short Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study
title_sort parietal lobe reorganization and widespread functional connectivity integration in upper-limb amputees: a rs-fmri study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329664/
https://www.ncbi.nlm.nih.gov/pubmed/34354568
http://dx.doi.org/10.3389/fnins.2021.704079
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