AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma

The STING and absent in melanoma 2 (AIM2) pathways are activated by the presence of cytosolic DNA, and STING agonists enhance immunotherapeutic responses. Here, we show that dendritic cell (DC) expression of AIM2 within human melanoma correlates with poor prognosis and, in contrast to STING, AIM2 ex...

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Detalles Bibliográficos
Autores principales: Fukuda, Keitaro, Okamura, Ken, Riding, Rebecca L., Fan, Xueli, Afshari, Khashayar, Haddadi, Nazgol-Sadat, McCauley, Sean M., Guney, Mehmet H., Luban, Jeremy, Funakoshi, Takeru, Yaguchi, Tomonori, Kawakami, Yutaka, Khvorova, Anastasia, Fitzgerald, Katherine A., Harris, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329870/
https://www.ncbi.nlm.nih.gov/pubmed/34325468
http://dx.doi.org/10.1084/jem.20200962

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