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Role of reactive oxygen species in tumors based on the ‘seed and soil’ theory: A complex interaction

Tumor microenvironment (TME) can serve as the ‘soil’ for the growth and survival of tumor cells and function synergically with tumor cells to mediate tumor progression and therapeutic resistance. Reactive oxygen species (ROS) is somewhat of a double-edged sword for tumors. Accumulating evidence has...

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Detalles Bibliográficos
Autores principales: Liang, Wei, He, Xinying, Bi, Jianqiang, Hu, Tingting, Sun, Yunchuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329912/
https://www.ncbi.nlm.nih.gov/pubmed/34328200
http://dx.doi.org/10.3892/or.2021.8159
Descripción
Sumario:Tumor microenvironment (TME) can serve as the ‘soil’ for the growth and survival of tumor cells and function synergically with tumor cells to mediate tumor progression and therapeutic resistance. Reactive oxygen species (ROS) is somewhat of a double-edged sword for tumors. Accumulating evidence has reported that regulating ROS levels can serve an anti-tumor role in the TME, including the promotion of cancer cell apoptosis, inhibition of angiogenesis, preventing immune escape, manipulating tumor metabolic reorganization and improving drug resistance. In the present review, the potential role of ROS in anti-tumor therapy was summarized, including the possibility of directly or indirectly targeting the TME.