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The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis
BACKGROUND: The purpose of this study was to evaluate the diagnostic and prognostic significance of miR-211-5p in atherosclerosis (AS) by detecting the expression level in serum of patients with AS. METHODS: A total of 85 healthy controls and 90 asymptomatic AS patients participated in this study. T...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330028/ https://www.ncbi.nlm.nih.gov/pubmed/34340677 http://dx.doi.org/10.1186/s12872-021-02187-z |
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author | Zhang, Yanxia Wang, Huiyun Xia, Yu |
author_facet | Zhang, Yanxia Wang, Huiyun Xia, Yu |
author_sort | Zhang, Yanxia |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to evaluate the diagnostic and prognostic significance of miR-211-5p in atherosclerosis (AS) by detecting the expression level in serum of patients with AS. METHODS: A total of 85 healthy controls and 90 asymptomatic AS patients participated in this study. The expression level of miR-211-5p in all subjects were measured by qRT-PCR. Spearman correlation coefficient was used to evaluate the correlation of miR-211-5p with CRP and CIMT. The ROC curve was established to assess the diagnostic value of miR-211-5p in AS. The Kaplan–Meier survival curve and multivariate COX regression analysis were used to evaluate the prognostic significance of miR-211-5p in AS. RESULTS: The expression levels of miR-211-5p in AS patients were significantly lower than in healthy controls (P < 0.001), and miR-211-5p showed a significant negative correlation with CRP (r = − 0.639, P < 0.001) and CIMT (r = − 0.730, P < 0.001). The AUC of the ROC curve was 0.900, the specificity and the sensitivity were 84.7% and 78.9%, respectively, which indicating that miR-211-5p had diagnostic value for AS. Survival analysis showed that patients with low miR-211-5p expression were more likely to have cardiovascular end-point events (Log rank P = 0.013). CONCLUSION: Serum miR-211-5p could be used as a new biomarker for the diagnosis of AS, and the low expression of miR-211-5p is associated with the poor prognosis of AS. |
format | Online Article Text |
id | pubmed-8330028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-83300282021-08-03 The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis Zhang, Yanxia Wang, Huiyun Xia, Yu BMC Cardiovasc Disord Research BACKGROUND: The purpose of this study was to evaluate the diagnostic and prognostic significance of miR-211-5p in atherosclerosis (AS) by detecting the expression level in serum of patients with AS. METHODS: A total of 85 healthy controls and 90 asymptomatic AS patients participated in this study. The expression level of miR-211-5p in all subjects were measured by qRT-PCR. Spearman correlation coefficient was used to evaluate the correlation of miR-211-5p with CRP and CIMT. The ROC curve was established to assess the diagnostic value of miR-211-5p in AS. The Kaplan–Meier survival curve and multivariate COX regression analysis were used to evaluate the prognostic significance of miR-211-5p in AS. RESULTS: The expression levels of miR-211-5p in AS patients were significantly lower than in healthy controls (P < 0.001), and miR-211-5p showed a significant negative correlation with CRP (r = − 0.639, P < 0.001) and CIMT (r = − 0.730, P < 0.001). The AUC of the ROC curve was 0.900, the specificity and the sensitivity were 84.7% and 78.9%, respectively, which indicating that miR-211-5p had diagnostic value for AS. Survival analysis showed that patients with low miR-211-5p expression were more likely to have cardiovascular end-point events (Log rank P = 0.013). CONCLUSION: Serum miR-211-5p could be used as a new biomarker for the diagnosis of AS, and the low expression of miR-211-5p is associated with the poor prognosis of AS. BioMed Central 2021-08-02 /pmc/articles/PMC8330028/ /pubmed/34340677 http://dx.doi.org/10.1186/s12872-021-02187-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhang, Yanxia Wang, Huiyun Xia, Yu The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis |
title | The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis |
title_full | The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis |
title_fullStr | The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis |
title_full_unstemmed | The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis |
title_short | The expression of miR-211-5p in atherosclerosis and its influence on diagnosis and prognosis |
title_sort | expression of mir-211-5p in atherosclerosis and its influence on diagnosis and prognosis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330028/ https://www.ncbi.nlm.nih.gov/pubmed/34340677 http://dx.doi.org/10.1186/s12872-021-02187-z |
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