Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration

BACKGROUND: Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into individual granulin peptides, which are increasingl...

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Detalles Bibliográficos
Autores principales: Mohan, Swetha, Sampognaro, Paul J., Argouarch, Andrea R., Maynard, Jason C., Welch, Mackenzie, Patwardhan, Anand, Courtney, Emma C., Zhang, Jiasheng, Mason, Amanda, Li, Kathy H., Huang, Eric J., Seeley, William W., Miller, Bruce L., Burlingame, Alma, Jacobson, Mathew P., Kao, Aimee W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330050/
https://www.ncbi.nlm.nih.gov/pubmed/34344440
http://dx.doi.org/10.1186/s13024-021-00472-1

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