Cargando…

Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine

Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in regenerative medicine. MenSC has received increasing attention owing to its impressive therapeutic effects in both preclinical and clinical trials. However, the study of MenSC-derived small extracellular vesicles (EVs) i...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Lijun, Qu, Jingjing, Mei, Quanhui, Chen, Xin, Fang, Yangxin, Chen, Lu, Li, Yifei, Xiang, Charlie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330084/
https://www.ncbi.nlm.nih.gov/pubmed/34344458
http://dx.doi.org/10.1186/s13287-021-02511-6
_version_ 1783732629033451520
author Chen, Lijun
Qu, Jingjing
Mei, Quanhui
Chen, Xin
Fang, Yangxin
Chen, Lu
Li, Yifei
Xiang, Charlie
author_facet Chen, Lijun
Qu, Jingjing
Mei, Quanhui
Chen, Xin
Fang, Yangxin
Chen, Lu
Li, Yifei
Xiang, Charlie
author_sort Chen, Lijun
collection PubMed
description Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in regenerative medicine. MenSC has received increasing attention owing to its impressive therapeutic effects in both preclinical and clinical trials. However, the study of MenSC-derived small extracellular vesicles (EVs) is still in its initial stages, in contrast to some common MSC sources (e.g., bone marrow, umbilical cord, and adipose tissue). We describe the basic characteristics and biological functions of MenSC-derived small EVs. We also demonstrate the therapeutic potential of small EVs in fulminant hepatic failure, myocardial infarction, pulmonary fibrosis, prostate cancer, cutaneous wound, type-1 diabetes mellitus, aged fertility, and potential diseases. Subsequently, novel hotspots with respect to MenSC EV-based therapy are proposed to overcome current challenges. While complexities regarding the therapeutic potential of MenSC EVs continue to be unraveled, advances are rapidly emerging in both basic science and clinical medicine. MenSC EV-based treatment has great potential for treating a series of diseases as a novel therapeutic strategy in regenerative medicine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-021-02511-6.
format Online
Article
Text
id pubmed-8330084
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-83300842021-08-04 Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine Chen, Lijun Qu, Jingjing Mei, Quanhui Chen, Xin Fang, Yangxin Chen, Lu Li, Yifei Xiang, Charlie Stem Cell Res Ther Review Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in regenerative medicine. MenSC has received increasing attention owing to its impressive therapeutic effects in both preclinical and clinical trials. However, the study of MenSC-derived small extracellular vesicles (EVs) is still in its initial stages, in contrast to some common MSC sources (e.g., bone marrow, umbilical cord, and adipose tissue). We describe the basic characteristics and biological functions of MenSC-derived small EVs. We also demonstrate the therapeutic potential of small EVs in fulminant hepatic failure, myocardial infarction, pulmonary fibrosis, prostate cancer, cutaneous wound, type-1 diabetes mellitus, aged fertility, and potential diseases. Subsequently, novel hotspots with respect to MenSC EV-based therapy are proposed to overcome current challenges. While complexities regarding the therapeutic potential of MenSC EVs continue to be unraveled, advances are rapidly emerging in both basic science and clinical medicine. MenSC EV-based treatment has great potential for treating a series of diseases as a novel therapeutic strategy in regenerative medicine. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13287-021-02511-6. BioMed Central 2021-08-03 /pmc/articles/PMC8330084/ /pubmed/34344458 http://dx.doi.org/10.1186/s13287-021-02511-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Lijun
Qu, Jingjing
Mei, Quanhui
Chen, Xin
Fang, Yangxin
Chen, Lu
Li, Yifei
Xiang, Charlie
Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
title Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
title_full Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
title_fullStr Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
title_full_unstemmed Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
title_short Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
title_sort small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (menscs) as a novel therapeutic impetus in regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330084/
https://www.ncbi.nlm.nih.gov/pubmed/34344458
http://dx.doi.org/10.1186/s13287-021-02511-6
work_keys_str_mv AT chenlijun smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine
AT qujingjing smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine
AT meiquanhui smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine
AT chenxin smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine
AT fangyangxin smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine
AT chenlu smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine
AT liyifei smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine
AT xiangcharlie smallextracellularvesiclesfrommenstrualbloodderivedmesenchymalstemcellsmenscsasanoveltherapeuticimpetusinregenerativemedicine