Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review

Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous systems. NPY affects the nutritional and inflammatory microenvironments through its interactio...

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Autores principales: Zhang, Yan, Liu, Chu-Yun, Chen, Wei-Can, Shi, Yan-Chuan, Wang, Cong-Mei, Lin, Shu, He, He-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330085/
https://www.ncbi.nlm.nih.gov/pubmed/34344469
http://dx.doi.org/10.1186/s13578-021-00657-7
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author Zhang, Yan
Liu, Chu-Yun
Chen, Wei-Can
Shi, Yan-Chuan
Wang, Cong-Mei
Lin, Shu
He, He-Fan
author_facet Zhang, Yan
Liu, Chu-Yun
Chen, Wei-Can
Shi, Yan-Chuan
Wang, Cong-Mei
Lin, Shu
He, He-Fan
author_sort Zhang, Yan
collection PubMed
description Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous systems. NPY affects the nutritional and inflammatory microenvironments through its interaction with immune cells, brain-derived trophic factor (BDNF), and angiogenesis promotion to maintain body homeostasis. Additionally, NPY has great potential for therapeutic applications against various diseases, especially as an adjuvant therapy for stem cells. In this review, we discuss the research progress regarding NPY, as well as the current evidence for the regulation of NPY in each microenvironment, and provide prospects for further research on related diseases.
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spelling pubmed-83300852021-08-04 Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review Zhang, Yan Liu, Chu-Yun Chen, Wei-Can Shi, Yan-Chuan Wang, Cong-Mei Lin, Shu He, He-Fan Cell Biosci Review Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous systems. NPY affects the nutritional and inflammatory microenvironments through its interaction with immune cells, brain-derived trophic factor (BDNF), and angiogenesis promotion to maintain body homeostasis. Additionally, NPY has great potential for therapeutic applications against various diseases, especially as an adjuvant therapy for stem cells. In this review, we discuss the research progress regarding NPY, as well as the current evidence for the regulation of NPY in each microenvironment, and provide prospects for further research on related diseases. BioMed Central 2021-08-03 /pmc/articles/PMC8330085/ /pubmed/34344469 http://dx.doi.org/10.1186/s13578-021-00657-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Yan
Liu, Chu-Yun
Chen, Wei-Can
Shi, Yan-Chuan
Wang, Cong-Mei
Lin, Shu
He, He-Fan
Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review
title Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review
title_full Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review
title_fullStr Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review
title_full_unstemmed Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review
title_short Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review
title_sort regulation of neuropeptide y in body microenvironments and its potential application in therapies: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330085/
https://www.ncbi.nlm.nih.gov/pubmed/34344469
http://dx.doi.org/10.1186/s13578-021-00657-7
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