Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM’s holistic concept and differentiation...

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Autores principales: Dai, Xianmin, Feng, Jiayi, Chen, Yi, Huang, Si, Shi, Xiaofei, Liu, Xia, Sun, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330116/
https://www.ncbi.nlm.nih.gov/pubmed/34344394
http://dx.doi.org/10.1186/s13020-021-00469-4
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author Dai, Xianmin
Feng, Jiayi
Chen, Yi
Huang, Si
Shi, Xiaofei
Liu, Xia
Sun, Yang
author_facet Dai, Xianmin
Feng, Jiayi
Chen, Yi
Huang, Si
Shi, Xiaofei
Liu, Xia
Sun, Yang
author_sort Dai, Xianmin
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM’s holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. However, the multi-compounds and multi-targets are big obstacle for the study of TCM. Here, we summarize the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds. The combined mechanism of herbs in TCM compounds are further discussed to explore their comprehensive effects on NAFLD. This article aims to summarize multiple functions and find the common ground for TCM treatment on NAFLD, thus providing enrichment to the scientific connotation of TCM theories and promotes the exploration of TCM therapies on NAFLD.
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spelling pubmed-83301162021-08-04 Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives Dai, Xianmin Feng, Jiayi Chen, Yi Huang, Si Shi, Xiaofei Liu, Xia Sun, Yang Chin Med Review Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in hepatic diseases for centuries in Asia, and TCM’s holistic concept and differentiation treatment of NAFLD show their advantages in the treatment of this complex metabolic disease. However, the multi-compounds and multi-targets are big obstacle for the study of TCM. Here, we summarize the pharmacological actions of active ingredients from frequently used single herbs in TCM compounds. The combined mechanism of herbs in TCM compounds are further discussed to explore their comprehensive effects on NAFLD. This article aims to summarize multiple functions and find the common ground for TCM treatment on NAFLD, thus providing enrichment to the scientific connotation of TCM theories and promotes the exploration of TCM therapies on NAFLD. BioMed Central 2021-08-03 /pmc/articles/PMC8330116/ /pubmed/34344394 http://dx.doi.org/10.1186/s13020-021-00469-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Dai, Xianmin
Feng, Jiayi
Chen, Yi
Huang, Si
Shi, Xiaofei
Liu, Xia
Sun, Yang
Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives
title Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives
title_full Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives
title_fullStr Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives
title_full_unstemmed Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives
title_short Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives
title_sort traditional chinese medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330116/
https://www.ncbi.nlm.nih.gov/pubmed/34344394
http://dx.doi.org/10.1186/s13020-021-00469-4
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